Biochemical effects of minaprine on striatal dopaminergic neurons in rats

P. Ferretti, S. Algeri, F. Benfenati, M. Cimino, C. Ferretti, S. Garattini, M. Lipartiti

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

The biochemical effects of minaprine, a new psychotropic drug, were investigated on striatal dopaminergic neurons in the rat. Minaprine did not displace [3H]spiperone in-vitro binding from striatal membranes but had clear effects on dopamine (DA) metabolites. Homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly decreased in a dose-dependent manner after intraperitoneal administration of minaprine 30 min before killing. In rats injected with minaprine 15 mg kg-1 i.p. at different intervals, the decrease in striatal HVA and DOPAC was time-dependent and a concomitant rise in 3-methoxytryramine (3-MT) concentrations was observed. The maximum of these effects was reached 30 min after minaprine. When administered 5 min after a monoamineoxidase (MAO) inhibitor (pargyline, 100 mg kg-1 i.p.) and 30 min before killing, minaprine did not affect pargyline-induced changes in HVA, DOPAC and 3-MT levels. This together with other data suggests that minaprine affects DA metabolism by acting, at least partially, at presynaptic level through in vivo inhibition of MAO activity.

Original languageEnglish
Pages (from-to)48-50
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number1
Publication statusPublished - 1984

Fingerprint

Corpus Striatum
Dopaminergic Neurons
Homovanillic Acid
Pargyline
Acids
Dopamine
Spiperone
Psychotropic Drugs
minaprine
Membranes

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Ferretti, P., Algeri, S., Benfenati, F., Cimino, M., Ferretti, C., Garattini, S., & Lipartiti, M. (1984). Biochemical effects of minaprine on striatal dopaminergic neurons in rats. Journal of Pharmacy and Pharmacology, 36(1), 48-50.

Biochemical effects of minaprine on striatal dopaminergic neurons in rats. / Ferretti, P.; Algeri, S.; Benfenati, F.; Cimino, M.; Ferretti, C.; Garattini, S.; Lipartiti, M.

In: Journal of Pharmacy and Pharmacology, Vol. 36, No. 1, 1984, p. 48-50.

Research output: Contribution to journalArticle

Ferretti, P, Algeri, S, Benfenati, F, Cimino, M, Ferretti, C, Garattini, S & Lipartiti, M 1984, 'Biochemical effects of minaprine on striatal dopaminergic neurons in rats', Journal of Pharmacy and Pharmacology, vol. 36, no. 1, pp. 48-50.
Ferretti P, Algeri S, Benfenati F, Cimino M, Ferretti C, Garattini S et al. Biochemical effects of minaprine on striatal dopaminergic neurons in rats. Journal of Pharmacy and Pharmacology. 1984;36(1):48-50.
Ferretti, P. ; Algeri, S. ; Benfenati, F. ; Cimino, M. ; Ferretti, C. ; Garattini, S. ; Lipartiti, M. / Biochemical effects of minaprine on striatal dopaminergic neurons in rats. In: Journal of Pharmacy and Pharmacology. 1984 ; Vol. 36, No. 1. pp. 48-50.
@article{40c74548e7fe47de8a2b07f26b96aeac,
title = "Biochemical effects of minaprine on striatal dopaminergic neurons in rats",
abstract = "The biochemical effects of minaprine, a new psychotropic drug, were investigated on striatal dopaminergic neurons in the rat. Minaprine did not displace [3H]spiperone in-vitro binding from striatal membranes but had clear effects on dopamine (DA) metabolites. Homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly decreased in a dose-dependent manner after intraperitoneal administration of minaprine 30 min before killing. In rats injected with minaprine 15 mg kg-1 i.p. at different intervals, the decrease in striatal HVA and DOPAC was time-dependent and a concomitant rise in 3-methoxytryramine (3-MT) concentrations was observed. The maximum of these effects was reached 30 min after minaprine. When administered 5 min after a monoamineoxidase (MAO) inhibitor (pargyline, 100 mg kg-1 i.p.) and 30 min before killing, minaprine did not affect pargyline-induced changes in HVA, DOPAC and 3-MT levels. This together with other data suggests that minaprine affects DA metabolism by acting, at least partially, at presynaptic level through in vivo inhibition of MAO activity.",
author = "P. Ferretti and S. Algeri and F. Benfenati and M. Cimino and C. Ferretti and S. Garattini and M. Lipartiti",
year = "1984",
language = "English",
volume = "36",
pages = "48--50",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
number = "1",

}

TY - JOUR

T1 - Biochemical effects of minaprine on striatal dopaminergic neurons in rats

AU - Ferretti, P.

AU - Algeri, S.

AU - Benfenati, F.

AU - Cimino, M.

AU - Ferretti, C.

AU - Garattini, S.

AU - Lipartiti, M.

PY - 1984

Y1 - 1984

N2 - The biochemical effects of minaprine, a new psychotropic drug, were investigated on striatal dopaminergic neurons in the rat. Minaprine did not displace [3H]spiperone in-vitro binding from striatal membranes but had clear effects on dopamine (DA) metabolites. Homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly decreased in a dose-dependent manner after intraperitoneal administration of minaprine 30 min before killing. In rats injected with minaprine 15 mg kg-1 i.p. at different intervals, the decrease in striatal HVA and DOPAC was time-dependent and a concomitant rise in 3-methoxytryramine (3-MT) concentrations was observed. The maximum of these effects was reached 30 min after minaprine. When administered 5 min after a monoamineoxidase (MAO) inhibitor (pargyline, 100 mg kg-1 i.p.) and 30 min before killing, minaprine did not affect pargyline-induced changes in HVA, DOPAC and 3-MT levels. This together with other data suggests that minaprine affects DA metabolism by acting, at least partially, at presynaptic level through in vivo inhibition of MAO activity.

AB - The biochemical effects of minaprine, a new psychotropic drug, were investigated on striatal dopaminergic neurons in the rat. Minaprine did not displace [3H]spiperone in-vitro binding from striatal membranes but had clear effects on dopamine (DA) metabolites. Homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly decreased in a dose-dependent manner after intraperitoneal administration of minaprine 30 min before killing. In rats injected with minaprine 15 mg kg-1 i.p. at different intervals, the decrease in striatal HVA and DOPAC was time-dependent and a concomitant rise in 3-methoxytryramine (3-MT) concentrations was observed. The maximum of these effects was reached 30 min after minaprine. When administered 5 min after a monoamineoxidase (MAO) inhibitor (pargyline, 100 mg kg-1 i.p.) and 30 min before killing, minaprine did not affect pargyline-induced changes in HVA, DOPAC and 3-MT levels. This together with other data suggests that minaprine affects DA metabolism by acting, at least partially, at presynaptic level through in vivo inhibition of MAO activity.

UR - http://www.scopus.com/inward/record.url?scp=0021351429&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021351429&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 48

EP - 50

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 1

ER -