Biochemical effects of minaprine on striatal dopaminergic neurons in rats

P. Ferretti, S. Algeri, F. Benfenati, M. Cimino, C. Ferretti, S. Garattini, M. Lipartiti

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Abstract

The biochemical effects of minaprine, a new psychotropic drug, were investigated on striatal dopaminergic neurons in the rat. Minaprine did not displace [3H]spiperone in-vitro binding from striatal membranes but had clear effects on dopamine (DA) metabolites. Homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) were significantly decreased in a dose-dependent manner after intraperitoneal administration of minaprine 30 min before killing. In rats injected with minaprine 15 mg kg-1 i.p. at different intervals, the decrease in striatal HVA and DOPAC was time-dependent and a concomitant rise in 3-methoxytryramine (3-MT) concentrations was observed. The maximum of these effects was reached 30 min after minaprine. When administered 5 min after a monoamineoxidase (MAO) inhibitor (pargyline, 100 mg kg-1 i.p.) and 30 min before killing, minaprine did not affect pargyline-induced changes in HVA, DOPAC and 3-MT levels. This together with other data suggests that minaprine affects DA metabolism by acting, at least partially, at presynaptic level through in vivo inhibition of MAO activity.

Original languageEnglish
Pages (from-to)48-50
Number of pages3
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number1
Publication statusPublished - 1984

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science

Cite this

Ferretti, P., Algeri, S., Benfenati, F., Cimino, M., Ferretti, C., Garattini, S., & Lipartiti, M. (1984). Biochemical effects of minaprine on striatal dopaminergic neurons in rats. Journal of Pharmacy and Pharmacology, 36(1), 48-50.