Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives

R. Antonicelli, E. Balducci, G. Lipponi, C. Lucantoni, R. Gaetti, E. Paciaroni

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Abstract

The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 ± 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na +/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 ± 50.3 μmol Na+ RBC 1 -1.h-1, after 1 month of urapidil therapy: 181.5 ± 89.3 ILmol Na+ RBC 1-1.h-1) (P

Original languageEnglish
Pages (from-to)252-255
Number of pages4
JournalPostgraduate Medical Journal
Volume67
Issue number785
DOIs
Publication statusPublished - 1991

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ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

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