TY - JOUR
T1 - Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives
AU - Antonicelli, R.
AU - Balducci, E.
AU - Lipponi, G.
AU - Lucantoni, C.
AU - Gaetti, R.
AU - Paciaroni, E.
PY - 1991
Y1 - 1991
N2 - The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 ± 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na +/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 ± 50.3 μmol Na+ RBC 1 -1.h-1, after 1 month of urapidil therapy: 181.5 ± 89.3 ILmol Na+ RBC 1-1.h-1) (P
AB - The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 ± 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na +/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 ± 50.3 μmol Na+ RBC 1 -1.h-1, after 1 month of urapidil therapy: 181.5 ± 89.3 ILmol Na+ RBC 1-1.h-1) (P
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U2 - 10.1136/pgmj.67.785.252
DO - 10.1136/pgmj.67.785.252
M3 - Article
C2 - 2062772
AN - SCOPUS:0025778468
VL - 67
SP - 252
EP - 255
JO - Postgraduate Medical Journal
JF - Postgraduate Medical Journal
SN - 0032-5473
IS - 785
ER -