Abstract
The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 ± 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na +/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 ± 50.3 μmol Na+ RBC 1 -1.h-1, after 1 month of urapidil therapy: 181.5 ± 89.3 ILmol Na+ RBC 1-1.h-1) (P
| Original language | English |
|---|---|
| Pages (from-to) | 252-255 |
| Number of pages | 4 |
| Journal | Postgraduate Medical Journal |
| Volume | 67 |
| Issue number | 785 |
| DOIs | |
| Publication status | Published - 1991 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Epidemiology
- Medicine(all)
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Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives. / Antonicelli, R.; Balducci, E.; Lipponi, G.; Lucantoni, C.; Gaetti, R.; Paciaroni, E.
In: Postgraduate Medical Journal, Vol. 67, No. 785, 1991, p. 252-255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives
AU - Antonicelli, R.
AU - Balducci, E.
AU - Lipponi, G.
AU - Lucantoni, C.
AU - Gaetti, R.
AU - Paciaroni, E.
PY - 1991
Y1 - 1991
N2 - The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 ± 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na +/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 ± 50.3 μmol Na+ RBC 1 -1.h-1, after 1 month of urapidil therapy: 181.5 ± 89.3 ILmol Na+ RBC 1-1.h-1) (P
AB - The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 ± 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na +/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 ± 50.3 μmol Na+ RBC 1 -1.h-1, after 1 month of urapidil therapy: 181.5 ± 89.3 ILmol Na+ RBC 1-1.h-1) (P
UR - http://www.scopus.com/inward/record.url?scp=0025778468&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025778468&partnerID=8YFLogxK
U2 - 10.1136/pgmj.67.785.252
DO - 10.1136/pgmj.67.785.252
M3 - Article
C2 - 2062772
AN - SCOPUS:0025778468
VL - 67
SP - 252
EP - 255
JO - Postgraduate Medical Journal
JF - Postgraduate Medical Journal
SN - 0032-5473
IS - 785
ER -