Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives

R. Antonicelli, E. Balducci, G. Lipponi, C. Lucantoni, R. Gaetti, E. Paciaroni

Research output: Contribution to journalArticle

Abstract

The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 ± 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na +/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 ± 50.3 μmol Na+ RBC 1 -1.h-1, after 1 month of urapidil therapy: 181.5 ± 89.3 ILmol Na+ RBC 1-1.h-1) (P

Original languageEnglish
Pages (from-to)252-255
Number of pages4
JournalPostgraduate Medical Journal
Volume67
Issue number785
DOIs
Publication statusPublished - 1991

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Ion Transport
Cell Membrane
Population
Nystatin
Cross-Over Studies
Erythrocytes
Placebos
Membranes
urapidil
Therapeutics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Epidemiology
  • Medicine(all)

Cite this

Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives. / Antonicelli, R.; Balducci, E.; Lipponi, G.; Lucantoni, C.; Gaetti, R.; Paciaroni, E.

In: Postgraduate Medical Journal, Vol. 67, No. 785, 1991, p. 252-255.

Research output: Contribution to journalArticle

Antonicelli, R. ; Balducci, E. ; Lipponi, G. ; Lucantoni, C. ; Gaetti, R. ; Paciaroni, E. / Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives. In: Postgraduate Medical Journal. 1991 ; Vol. 67, No. 785. pp. 252-255.
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