Abstract
In three cases with calcification of the basal ganglia (two showing extrapyramidal symptoms, and one seizures), the CSF turnover of DA and 5-HT catabolites and the TIDA system were investigated. Probenecid induced an accumulation of HVA, and the changes after DA agonists treatment suggest a kind of 'inertness' involving different levels of the nigro-striatal system. No relationship was found with the clinical picture. In the patients with extrapyramidal disturbances, the PRL response after a DA blocker suggests a hypersensitivity of the TIDA receptors.
| Original language | English |
|---|---|
| Pages (from-to) | 231-239 |
| Number of pages | 9 |
| Journal | Acta Neurologica |
| Volume | 35 |
| Issue number | 4 |
| Publication status | Published - 1980 |
ASJC Scopus subject areas
- Clinical Neurology
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Savoldi, F., Nappi, G., Martignoni, E., & Bono, G. (1980). Biochemical evidence of dopaminergic involvement in Fahr's syndrome. Acta Neurologica, 35(4), 231-239.