Biochemical evidence of dopaminergic involvement in Fahr's syndrome

F. Savoldi; G. Nappi; E. Martignoni; G. Bono

Biochemical evidence of dopaminergic involvement in Fahr's syndrome

F. Savoldi, G. Nappi, E. Martignoni, G. Bono

Fondazione "Istituto Neurologico Casimiro Mondino"

Research output: Contribution to journal › Article › peer-review

Abstract

In three cases with calcification of the basal ganglia (two showing extrapyramidal symptoms, and one seizures), the CSF turnover of DA and 5-HT catabolites and the TIDA system were investigated. Probenecid induced an accumulation of HVA, and the changes after DA agonists treatment suggest a kind of 'inertness' involving different levels of the nigro-striatal system. No relationship was found with the clinical picture. In the patients with extrapyramidal disturbances, the PRL response after a DA blocker suggests a hypersensitivity of the TIDA receptors.

Original language	English
Pages (from-to)	231-239
Number of pages	9
Journal	Acta Neurologica
Volume	35
Issue number	4
Publication status	Published - 1980

ASJC Scopus subject areas

Clinical Neurology

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AU - Savoldi, F.

AU - Nappi, G.

AU - Martignoni, E.

AU - Bono, G.

PY - 1980

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Biochemical evidence of dopaminergic involvement in Fahr's syndrome

Abstract

ASJC Scopus subject areas

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