Biochemical evidence of dopaminergic involvement in Fahr's syndrome

F. Savoldi, G. Nappi, E. Martignoni, G. Bono

Research output: Contribution to journalArticle

Abstract

In three cases with calcification of the basal ganglia (two showing extrapyramidal symptoms, and one seizures), the CSF turnover of DA and 5-HT catabolites and the TIDA system were investigated. Probenecid induced an accumulation of HVA, and the changes after DA agonists treatment suggest a kind of 'inertness' involving different levels of the nigro-striatal system. No relationship was found with the clinical picture. In the patients with extrapyramidal disturbances, the PRL response after a DA blocker suggests a hypersensitivity of the TIDA receptors.

Original languageEnglish
Pages (from-to)231-239
Number of pages9
JournalActa Neurologica
Volume35
Issue number4
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Clinical Neurology

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    Savoldi, F., Nappi, G., Martignoni, E., & Bono, G. (1980). Biochemical evidence of dopaminergic involvement in Fahr's syndrome. Acta Neurologica, 35(4), 231-239.