Biochemical evidence of dopaminergic involvement in Fahr's syndrome

F. Savoldi, G. Nappi, E. Martignoni, G. Bono

Research output: Contribution to journalArticlepeer-review


In three cases with calcification of the basal ganglia (two showing extrapyramidal symptoms, and one seizures), the CSF turnover of DA and 5-HT catabolites and the TIDA system were investigated. Probenecid induced an accumulation of HVA, and the changes after DA agonists treatment suggest a kind of 'inertness' involving different levels of the nigro-striatal system. No relationship was found with the clinical picture. In the patients with extrapyramidal disturbances, the PRL response after a DA blocker suggests a hypersensitivity of the TIDA receptors.

Original languageEnglish
Pages (from-to)231-239
Number of pages9
JournalActa Neurologica
Issue number4
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Clinical Neurology


Dive into the research topics of 'Biochemical evidence of dopaminergic involvement in Fahr's syndrome'. Together they form a unique fingerprint.

Cite this