In three cases with calcification of the basal ganglia (two showing extrapyramidal symptoms, and one seizures), the CSF turnover of DA and 5-HT catabolites and the TIDA system were investigated. Probenecid induced an accumulation of HVA, and the changes after DA agonists treatment suggest a kind of 'inertness' involving different levels of the nigro-striatal system. No relationship was found with the clinical picture. In the patients with extrapyramidal disturbances, the PRL response after a DA blocker suggests a hypersensitivity of the TIDA receptors.
|Number of pages||9|
|Publication status||Published - 1980|
ASJC Scopus subject areas
- Clinical Neurology