Biochemical markers for detecting bone metastases in patients with breast cancer

L. Moro, C. Gazzarrini, D. Crivellari, E. Galligioni, R. Talamini, B. De Bernard

Research output: Contribution to journalArticle

Abstract

A study was carried out to assess the best use of biochemical bone markers to exclude metastases in patients with breast cancer. Urinary galactosyl- hydroxylysine and serum alkaline phosphatase were used to monitor bone resorption and deposition, respectively. Hydroxyproline was also measured. In a selected population of patients, possibly affected by metastases on the basis of scintigraphic examination, which is highly sensitive but poorly specific, we assessed the efficiency of the markers by a double statistical analysis. In this group, the only marker able to predict metastases was galactosyl-hydroxylysine.

Original languageEnglish
Pages (from-to)131-134
Number of pages4
JournalClinical Chemistry
Volume39
Issue number1
Publication statusPublished - 1993

Fingerprint

Hydroxylysine
Bone
Biomarkers
Breast Neoplasms
Neoplasm Metastasis
Bone and Bones
Hydroxyproline
Alkaline Phosphatase
Statistical methods
Bone Resorption
Serum
Population

Keywords

  • alkaline phosphatase
  • bone
  • galactosyl-hydroxylysine
  • hydroxyproline
  • receiver-operating characteristic curves
  • urine

ASJC Scopus subject areas

  • Clinical Biochemistry

Cite this

Moro, L., Gazzarrini, C., Crivellari, D., Galligioni, E., Talamini, R., & De Bernard, B. (1993). Biochemical markers for detecting bone metastases in patients with breast cancer. Clinical Chemistry, 39(1), 131-134.

Biochemical markers for detecting bone metastases in patients with breast cancer. / Moro, L.; Gazzarrini, C.; Crivellari, D.; Galligioni, E.; Talamini, R.; De Bernard, B.

In: Clinical Chemistry, Vol. 39, No. 1, 1993, p. 131-134.

Research output: Contribution to journalArticle

Moro, L, Gazzarrini, C, Crivellari, D, Galligioni, E, Talamini, R & De Bernard, B 1993, 'Biochemical markers for detecting bone metastases in patients with breast cancer', Clinical Chemistry, vol. 39, no. 1, pp. 131-134.
Moro L, Gazzarrini C, Crivellari D, Galligioni E, Talamini R, De Bernard B. Biochemical markers for detecting bone metastases in patients with breast cancer. Clinical Chemistry. 1993;39(1):131-134.
Moro, L. ; Gazzarrini, C. ; Crivellari, D. ; Galligioni, E. ; Talamini, R. ; De Bernard, B. / Biochemical markers for detecting bone metastases in patients with breast cancer. In: Clinical Chemistry. 1993 ; Vol. 39, No. 1. pp. 131-134.
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