I marcatori biochimici nella valutazione della cardiotossicità da farmaci antineoplastici: Analisi sistematica della letteratura e raccomandazioni per il loro utilizzo

Translated title of the contribution: Biochemical markers for predicting chemotherapy-induced cardiotoxicity: Systematic review of the literature and recommendations for use

Alberto Dolci, Roberto Dominici, Daniela Cardinale, Maria Teresa Sandri, Mauro Panteghini

Research output: Contribution to journalArticle

Abstract

Chemotherapy is a well established therapeutic approach for several malignancies, but its clinical efficacy is often limited by related cardiotoxicity leading to cardiomyopathy evolving towards heart failure that may worsen the patient outcome. To detect cardiac damage, the most frequently adopted diagnostic approach is the estimation of left ventricular ejection fraction by echocardiography, showing, however, low sensitivity in early prediction of cardiomyopathy, when appropriate treatments could still improve the patient's outcome. Cardiospecific biomarkers, like cardiac troponins, show high diagnostic efficacy in the early, subclinical phase of disease, becoming positive approximately 3 months before clinical onset of cardiomyopathy. Furthermore, the increase in their concentrations is well correlated with the disease severity and may predict the occurrence of major cardiac events during follow-up. On the other hand, negative troponin concentrations may identify patients with a very low risk of cardiomyopathy (negative predictive value = 99%). For cardiac natriuretic peptides, definitive evidence about a diagnostic or prognostic role in predicting chemotherapy-induced cardiomyopathy is lacking and their practical use in this context cannot be recommended until their clinical efficacy is clearly defined.

Translated title of the contributionBiochemical markers for predicting chemotherapy-induced cardiotoxicity: Systematic review of the literature and recommendations for use
Original languageItalian
Pages (from-to)604-611
Number of pages8
JournalGiornale Italiano di Cardiologia
Volume7
Issue number9
Publication statusPublished - Sep 2006

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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