Biochemical markers of perinatal brain damage

Pasquale Florio, Raul Abella, Emanuela Marinoni, Romolo Di Iorio, Giovanni Li Volti, Fabio Galvano, Giacomo Pongiglione, Alessandro Frigiola, Serena Pinzauti, Felice Petraglia, Diego Gazzolo

Research output: Contribution to journalArticle

Abstract

Hypoxia-ischemia constitutes a risk in infants by altering cerebral blood flow regulatory mechanisms and causing loss of cerebral vascular auto-regulation. Hypotension, cerebral ischemia, and reperfusion are the main events involved in vascular auto-regulation leading to cell death and tissue damage. These dramatic phenomena represent a common repertoire in infants complicated by perinatal acute or chronic hypoxia. To date, despite accurate perinatal and intra-operative monitoring, the post-insult period is crucial, since clinical symptoms and monitoring parameters may be of no avail and therapeutic window for pharmacological intervention (6-12 hours) may be limited, at a time when brain damage is already occurring. Therefore, the measurement of circulating biochemical markers of brain damage, such as vasoactive agents and nervous tissue peptides is eagerly awaited in clinical practice to detect high risk infants. The present review is aimed at investigating the role as circulating biochemical markers such as adrenomedullin, S100B, activin A, neuronal specific enolase (NSE), glial fibrillary acid protein (GFAP), in the cascade of events leading to ischemia reperfusion injury in infants complicated by perinatal asphyxia.

Original languageEnglish
Pages (from-to)47-72
Number of pages26
JournalFrontiers in Bioscience - Scholar
Volume2 S
Issue number1
Publication statusPublished - Jan 1 2010

    Fingerprint

Keywords

  • Activin A
  • Adrenomedullin
  • Brain Damage
  • GFAP
  • Hypoxia-Ischemia
  • NSE
  • Review
  • S100B

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Medicine(all)

Cite this

Florio, P., Abella, R., Marinoni, E., Di Iorio, R., Li Volti, G., Galvano, F., Pongiglione, G., Frigiola, A., Pinzauti, S., Petraglia, F., & Gazzolo, D. (2010). Biochemical markers of perinatal brain damage. Frontiers in Bioscience - Scholar, 2 S(1), 47-72.