Biochemical modulation of fluorouracil with high dose methotrexate or folinic acid in advanced colorectal cancer patients

G. Colucci, E. Maiello, S. Leo, F. Giuliani, A. Pedicini, G. Pezzella, V. Valori, D. Galetta, A. Contillo, F. Prete

Research output: Contribution to journalArticlepeer-review

Abstract

To compare the efficacy of two biochemical modulations of 5-Fluorouracil in advanced colorectal cancer, 104 patients were randomized to receive high dose methotrexate followed by 5-Fluorouracil and leucovorin rescue on day I (Arm A) or folinic acid and 5-Fluorouracil on day 1 to 5 (Arm B). Both treatments were repeated every 3 weeks. In the 92 evaluable patients, objective responses were observed in 34% in Arm A and 31% in Arm B, with a median duration of 7.5 and 8.5 months, respectively. Median overall survival was similar in both groups (12 versus 13 months, respectively). A statistically significant difference was found only between responders and non responders of group B (p = 0.004). Toxicity was mild. In conclusion, no difference in therapeutic activity was seen between the two treatments and additional biochemical modulation must be evaluated.

Original languageEnglish
Pages (from-to)2157-2162
Number of pages6
JournalAnticancer Research
Volume14
Issue number5 B
Publication statusPublished - 1994

Keywords

  • 5-Fluorouracil
  • Biochemical modulation
  • Colorectal cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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