Biochemical scores could reflect histological activity in chronic hepatitis C

R. Testa, A. Picciotto, G. Lapertosa, S. Caglieris, D. Risso, S. Borzone, N. Campo, S. Alvarez, G. Varagona, P. B. Lantieri, G. Celle

Research output: Contribution to journalArticlepeer-review

Abstract

Eighty-one patients with HCV positive chronic active hepatitis (CAH) were studied to correlate, in multivariate regression analysis, liver tests with the histological activity index (HAI). The median HAI value (9.4) divided the patients into two groups; 44 under the 9.4 value (moderate CAH) and 37 above (severe CAH). Multiple regression improved the significance of nine biochemical parameters related to HAI in univariate analysis, and backward stepwise analysis identified the combination of alanine-aminotransferase (ALT), gammaglobulins (γGL), gammaglutamyl transpeptidase (γGT) and prolyl-hydroxylase (PH) as the best relationship with HAI (R = 0.520, p <0.0001). A biochemical activity index (BAI) calculated as: 2.304 + ALT x 0.013 + γGL x 1.76 + γGT x 0.008 + PH x 0.012 showed the higher significant difference between moderate (7.7 ± 1.3) and severe (12.2 ± 2) CAH (p <0.0001). These results suggest that this BAI could be a pointer for checking activity of chronic liver diseases.

Original languageEnglish
Pages (from-to)437-441
Number of pages5
JournalItalian Journal of Gastroenterology
Volume26
Issue number9
Publication statusPublished - 1994

Keywords

  • Biochemical liver tests
  • Chronic active hepatitis
  • Histological activity index
  • Multivariate regression analysis

ASJC Scopus subject areas

  • Gastroenterology

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