TY - JOUR
T1 - Biochemical scores could reflect histological activity in chronic hepatitis C
AU - Testa, R.
AU - Picciotto, A.
AU - Lapertosa, G.
AU - Caglieris, S.
AU - Risso, D.
AU - Borzone, S.
AU - Campo, N.
AU - Alvarez, S.
AU - Varagona, G.
AU - Lantieri, P. B.
AU - Celle, G.
PY - 1994
Y1 - 1994
N2 - Eighty-one patients with HCV positive chronic active hepatitis (CAH) were studied to correlate, in multivariate regression analysis, liver tests with the histological activity index (HAI). The median HAI value (9.4) divided the patients into two groups; 44 under the 9.4 value (moderate CAH) and 37 above (severe CAH). Multiple regression improved the significance of nine biochemical parameters related to HAI in univariate analysis, and backward stepwise analysis identified the combination of alanine-aminotransferase (ALT), gammaglobulins (γGL), gammaglutamyl transpeptidase (γGT) and prolyl-hydroxylase (PH) as the best relationship with HAI (R = 0.520, p <0.0001). A biochemical activity index (BAI) calculated as: 2.304 + ALT x 0.013 + γGL x 1.76 + γGT x 0.008 + PH x 0.012 showed the higher significant difference between moderate (7.7 ± 1.3) and severe (12.2 ± 2) CAH (p <0.0001). These results suggest that this BAI could be a pointer for checking activity of chronic liver diseases.
AB - Eighty-one patients with HCV positive chronic active hepatitis (CAH) were studied to correlate, in multivariate regression analysis, liver tests with the histological activity index (HAI). The median HAI value (9.4) divided the patients into two groups; 44 under the 9.4 value (moderate CAH) and 37 above (severe CAH). Multiple regression improved the significance of nine biochemical parameters related to HAI in univariate analysis, and backward stepwise analysis identified the combination of alanine-aminotransferase (ALT), gammaglobulins (γGL), gammaglutamyl transpeptidase (γGT) and prolyl-hydroxylase (PH) as the best relationship with HAI (R = 0.520, p <0.0001). A biochemical activity index (BAI) calculated as: 2.304 + ALT x 0.013 + γGL x 1.76 + γGT x 0.008 + PH x 0.012 showed the higher significant difference between moderate (7.7 ± 1.3) and severe (12.2 ± 2) CAH (p <0.0001). These results suggest that this BAI could be a pointer for checking activity of chronic liver diseases.
KW - Biochemical liver tests
KW - Chronic active hepatitis
KW - Histological activity index
KW - Multivariate regression analysis
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M3 - Article
C2 - 7599344
AN - SCOPUS:0028567449
VL - 26
SP - 437
EP - 441
JO - Italian Journal of Gastroenterology
JF - Italian Journal of Gastroenterology
SN - 0392-0623
IS - 9
ER -