Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application

Cesare Achilli, Stefania Grandi, Annarita Ciana, Gianni F. Guidetti, Alessandro Malara, Vittorio Abbonante, Laura Cansolino, Corrado Tomasi, Alessandra Balduini, Maurizio Fagnoni, Daniele Merli, Piercarlo Mustarelli, Ilaria Canobbio, Cesare Balduini, Giampaolo Minetti

Research output: Contribution to journalArticle

Abstract

Boron neutron capture therapy (BNCT) is a radiotherapy treatment based on the accumulation in the tumor of a 10B-containing drug and subsequent irradiation with low energy neutrons, which bring about the decay of 10B to 7Li and an α particle, causing the death of the neoplastic cell. The effectiveness of BNCT is limited by the low delivery and accumulation of the used boron-containing compounds. Here we report the development and the characterization of BPO4 nanoparticles (NPs) as a novel possible alternative drug for BNCT. An extensive analysis of BPO4 NP biocompatibility was performed using both mature blood cells (erythrocytes, neutrophils and platelets) and a model of hematopoietic progenitor cells. A time- and concentration-dependent cytotoxicity study was performed on neoplastic coloncarcinoma and osteosarcoma cell lines. BPO4 functionalization with folic acid, introduced to improve the uptake by tumor cells, appeared to effectively limit the unwanted effects of NPs on the analyzed blood components.

Original languageEnglish
Pages (from-to)589-597
Number of pages9
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume10
Issue number3
DOIs
Publication statusPublished - 2014

Keywords

  • Blood cells
  • Boron-carrier
  • Cancer
  • Erythrocytes
  • Folic acid
  • Hemolysis
  • Nanomaterials
  • Neutrophils
  • Platelet aggregation

ASJC Scopus subject areas

  • Molecular Medicine
  • Bioengineering
  • Biomedical Engineering
  • Materials Science(all)
  • Medicine (miscellaneous)
  • Pharmaceutical Science

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  • Cite this

    Achilli, C., Grandi, S., Ciana, A., Guidetti, G. F., Malara, A., Abbonante, V., Cansolino, L., Tomasi, C., Balduini, A., Fagnoni, M., Merli, D., Mustarelli, P., Canobbio, I., Balduini, C., & Minetti, G. (2014). Biocompatibility of functionalized boron phosphate (BPO4) nanoparticles for boron neutron capture therapy (BNCT) application. Nanomedicine: Nanotechnology, Biology, and Medicine, 10(3), 589-597. https://doi.org/10.1016/j.nano.2013.10.003