Biodegradable PLGA matrix nanocomposite with silver nanoparticles

Material properties and bacteria activity

I. Armentano, E. Fortunati, L. Latterini, S. Rinaldi, E. Saino, L. Visai, F. Elisei, J. M. Kenny

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Poly(DL-Lactide-co-Glycolide) (PLGA) and silver (Ag) nanoparticles nanocomposite flms were produced by solvent casting using concentrations of Ag at 1 wt%, 5 wt% and 7 wt% with respect to the PLGA matrix. Field emission scanning electron microscopy (FESEM), confocal laser scanning microscopy (CLSM) and atomic force microscopy (AFM) investigations were performed to evaluate the nanohybrid morphology and the nanoparticle dispersion. Thermal properties were investigated by thermogravimetry (TGA). Surface properties were investigated by contact angle and optical absorption measurements. The results of the morphological analysis reveal that silver nanoparticles are able to induce changes of the polymer surface properties, increasing roughness and contact angle. The upper surface of the nanocomposites is characterized by a uniform round porous structure with pore diameter in the order of 10μm. The nanocomposite antibacterial activity as a function of nanoparticle content was tested against Escherichia coli bacteria. Results have been interpreted in terms of the assessed capacity of Ag nanoparticles to affect the bacteria adherence and growth on the tested nanocomposite surfaces that can be correlated with Ag loadings in the range analyzed, offering new perspectives in preventing biomaterial-associated infections.

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalJournal of Nanostructured Polymers and Nanocomposites
Volume6
Issue number4
Publication statusPublished - Oct 2010

Fingerprint

Silver
Materials properties
Nanocomposites
Bacteria
Nanoparticles
Contact angle
Surface properties
Biocompatible Materials
Biomaterials
Field emission
Light absorption
Escherichia coli
Thermogravimetric analysis
Atomic force microscopy
Microscopic examination
Polymers
Casting
Thermodynamic properties
Surface roughness
polylactic acid-polyglycolic acid copolymer

ASJC Scopus subject areas

  • Ceramics and Composites
  • Polymers and Plastics

Cite this

Biodegradable PLGA matrix nanocomposite with silver nanoparticles : Material properties and bacteria activity. / Armentano, I.; Fortunati, E.; Latterini, L.; Rinaldi, S.; Saino, E.; Visai, L.; Elisei, F.; Kenny, J. M.

In: Journal of Nanostructured Polymers and Nanocomposites, Vol. 6, No. 4, 10.2010, p. 110-117.

Research output: Contribution to journalArticle

Armentano, I, Fortunati, E, Latterini, L, Rinaldi, S, Saino, E, Visai, L, Elisei, F & Kenny, JM 2010, 'Biodegradable PLGA matrix nanocomposite with silver nanoparticles: Material properties and bacteria activity', Journal of Nanostructured Polymers and Nanocomposites, vol. 6, no. 4, pp. 110-117.
Armentano, I. ; Fortunati, E. ; Latterini, L. ; Rinaldi, S. ; Saino, E. ; Visai, L. ; Elisei, F. ; Kenny, J. M. / Biodegradable PLGA matrix nanocomposite with silver nanoparticles : Material properties and bacteria activity. In: Journal of Nanostructured Polymers and Nanocomposites. 2010 ; Vol. 6, No. 4. pp. 110-117.
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AU - Saino, E.

AU - Visai, L.

AU - Elisei, F.

AU - Kenny, J. M.

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