Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat

Marilyn P. Law; Safiye Osman; Raymond J. Davenport; Vincent J. Cunningham; Victor W. Pike; Paolo G. Camici

doi:10.1016/S0969-8051(97)00007-3

Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat

Marilyn P. Law, Safiye Osman, Raymond J. Davenport, Vincent J. Cunningham, Victor W. Pike, Paolo G. Camici

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Article › peer-review

Abstract

Biodistribution and metabolism of [N-methyb-¹¹C]-m-hydroxyephedrine ([¹¹C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [¹¹C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.

Original language	English
Pages (from-to)	417-424
Number of pages	8
Journal	Nuclear Medicine and Biology
Volume	24
Issue number	5
DOIs	https://doi.org/10.1016/S0969-8051(97)00007-3
Publication status	Published - Jul 1997

Keywords

Heart
Hydroxyephedrine
Metaraminol
Noradrenaline re-uptake
PET
Rat

ASJC Scopus subject areas

Cancer Research
Molecular Medicine
Radiology Nuclear Medicine and imaging

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10.1016/S0969-8051(97)00007-3

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title = "Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat",

abstract = "Biodistribution and metabolism of [N-methyb-11C]-m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.",

keywords = "Heart, Hydroxyephedrine, Metaraminol, Noradrenaline re-uptake, PET, Rat",

author = "Law, {Marilyn P.} and Safiye Osman and Davenport, {Raymond J.} and Cunningham, {Vincent J.} and Pike, {Victor W.} and Camici, {Paolo G.}",

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AU - Law, Marilyn P.

AU - Osman, Safiye

AU - Davenport, Raymond J.

AU - Cunningham, Vincent J.

AU - Pike, Victor W.

AU - Camici, Paolo G.

PY - 1997/7

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N2 - Biodistribution and metabolism of [N-methyb-11C]-m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.

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KW - Noradrenaline re-uptake

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