TY - JOUR
T1 - Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat
AU - Law, Marilyn P.
AU - Osman, Safiye
AU - Davenport, Raymond J.
AU - Cunningham, Vincent J.
AU - Pike, Victor W.
AU - Camici, Paolo G.
PY - 1997/7
Y1 - 1997/7
N2 - Biodistribution and metabolism of [N-methyb-11C]-m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.
AB - Biodistribution and metabolism of [N-methyb-11C]-m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.
KW - Heart
KW - Hydroxyephedrine
KW - Metaraminol
KW - Noradrenaline re-uptake
KW - PET
KW - Rat
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UR - http://www.scopus.com/inward/citedby.url?scp=0030876088&partnerID=8YFLogxK
U2 - 10.1016/S0969-8051(97)00007-3
DO - 10.1016/S0969-8051(97)00007-3
M3 - Article
C2 - 9290077
AN - SCOPUS:0030876088
VL - 24
SP - 417
EP - 424
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 5
ER -