Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat

Marilyn P. Law, Safiye Osman, Raymond J. Davenport, Vincent J. Cunningham, Victor W. Pike, Paolo G. Camici

Research output: Contribution to journal › Article

Abstract

Biodistribution and metabolism of [N-methyb-11C]-m-hydroxyephedrine ([11C]mHED), an analogue of noradrenaline, were assessed in rats. Pretreatment with desipramine, an uptake blocker, reduced uptake of radioactivity in myocardium but not in lung, liver, kidney, and muscle. Brain uptake was negligible. HPLC showed six radioactive metabolites in plasma and liver but none in myocardium. Co-injection of unlabelled mHED or metaraminol with [11C]mHED demonstrated no difference between the in vivo binding potentials for mHED and metaraminol in myocardium.

Original languageEnglish
Pages (from-to)417-424
Number of pages8
JournalNuclear Medicine and Biology
Volume24
Issue number5
DOIs
Publication statusPublished - Jul 1997

Fingerprint

Metaraminol
Myocardium
Desipramine
Liver
Radioactivity
Norepinephrine
High Pressure Liquid Chromatography
Kidney
Muscles
Lung
Injections
Brain
3-hydroxyephedrine

Keywords

  • Heart
  • Hydroxyephedrine
  • Metaraminol
  • Noradrenaline re-uptake
  • PET
  • Rat

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging

Cite this

Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat. / Law, Marilyn P.; Osman, Safiye; Davenport, Raymond J.; Cunningham, Vincent J.; Pike, Victor W.; Camici, Paolo G.

In: Nuclear Medicine and Biology, Vol. 24, No. 5, 07.1997, p. 417-424.

Research output: Contribution to journal › Article

Law, MP, Osman, S, Davenport, RJ, Cunningham, VJ, Pike, VW & Camici, PG 1997, 'Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat', Nuclear Medicine and Biology, vol. 24, no. 5, pp. 417-424. https://doi.org/10.1016/S0969-8051(97)00007-3
Law MP, Osman S, Davenport RJ, Cunningham VJ, Pike VW, Camici PG. Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat. Nuclear Medicine and Biology. 1997 Jul;24(5):417-424. https://doi.org/10.1016/S0969-8051(97)00007-3
Law, Marilyn P. ; Osman, Safiye ; Davenport, Raymond J. ; Cunningham, Vincent J. ; Pike, Victor W. ; Camici, Paolo G. / Biodistribution and metabolism of [N-methyl-11C]-m-hydroxyephedrine in the rat. In: Nuclear Medicine and Biology. 1997 ; Vol. 24, No. 5. pp. 417-424.
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