TY - JOUR
T1 - Biodistribution of haematoporphyrin analogues in a lung carcinoma model
AU - Tronconi, Marco
AU - Colombo, Ambrogio
AU - De Cesare, Michelandrea
AU - Marchesini, Renato
AU - Woodburn, Kathryn W.
AU - Reiss, James A.
AU - Phillips, Don R.
AU - Zunino, Franco
PY - 1995/1/6
Y1 - 1995/1/6
N2 - In an attempt to identify novel compounds useful for the optimization of Photodynamic Therapy (PDT), the tissue localization of new synthetic porphyrins was compared with Photofrin II in nude mice xenografted with a human small cell lung cancer (POVD). Three haematoporphyrin analogues were selected for this study based on prior in vitro photosensitivity screening of a series of 15 such derivatives, as well as on the basis of improved localization in C6 gliomas in mice. Two of the porphyrins yielded better tumour:normal lung ratios than Photofrin II and, of these two, one (P13) is known to exhibit good photosensitization properties both in vitro and in vivo, and is therefore a good candidate as a lead compound for the development of porphyrins suitable for the photodynamic treatment of lung tumours.
AB - In an attempt to identify novel compounds useful for the optimization of Photodynamic Therapy (PDT), the tissue localization of new synthetic porphyrins was compared with Photofrin II in nude mice xenografted with a human small cell lung cancer (POVD). Three haematoporphyrin analogues were selected for this study based on prior in vitro photosensitivity screening of a series of 15 such derivatives, as well as on the basis of improved localization in C6 gliomas in mice. Two of the porphyrins yielded better tumour:normal lung ratios than Photofrin II and, of these two, one (P13) is known to exhibit good photosensitization properties both in vitro and in vivo, and is therefore a good candidate as a lead compound for the development of porphyrins suitable for the photodynamic treatment of lung tumours.
KW - Haematoporphyrin derivatives
KW - Small cell lung cancer
KW - Tissue distribution
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U2 - 10.1016/0304-3835(94)03612-M
DO - 10.1016/0304-3835(94)03612-M
M3 - Article
C2 - 7850772
AN - SCOPUS:0028821338
VL - 88
SP - 41
EP - 48
JO - Cancer Letters
JF - Cancer Letters
SN - 0304-3835
IS - 1
ER -