Biodistribution of haematoporphyrin analogues in a lung carcinoma model

Marco Tronconi, Ambrogio Colombo, Michelandrea De Cesare, Renato Marchesini, Kathryn W. Woodburn, James A. Reiss, Don R. Phillips, Franco Zunino

Research output: Contribution to journalArticle

Abstract

In an attempt to identify novel compounds useful for the optimization of Photodynamic Therapy (PDT), the tissue localization of new synthetic porphyrins was compared with Photofrin II in nude mice xenografted with a human small cell lung cancer (POVD). Three haematoporphyrin analogues were selected for this study based on prior in vitro photosensitivity screening of a series of 15 such derivatives, as well as on the basis of improved localization in C6 gliomas in mice. Two of the porphyrins yielded better tumour:normal lung ratios than Photofrin II and, of these two, one (P13) is known to exhibit good photosensitization properties both in vitro and in vivo, and is therefore a good candidate as a lead compound for the development of porphyrins suitable for the photodynamic treatment of lung tumours.

Original languageEnglish
Pages (from-to)41-48
Number of pages8
JournalCancer Letters
Volume88
Issue number1
DOIs
Publication statusPublished - Jan 6 1995

Keywords

  • Haematoporphyrin derivatives
  • Small cell lung cancer
  • Tissue distribution

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Molecular Biology

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    Tronconi, M., Colombo, A., De Cesare, M., Marchesini, R., Woodburn, K. W., Reiss, J. A., Phillips, D. R., & Zunino, F. (1995). Biodistribution of haematoporphyrin analogues in a lung carcinoma model. Cancer Letters, 88(1), 41-48. https://doi.org/10.1016/0304-3835(94)03612-M