Noninvasive evaluation of the effects of clinical materials applied to skin can be achieved with bioengineering techniques. Transepidermal water loss, transepidermal chloride flux, transcutaneous CO2 transport and stratum corneum water content provide information on the functional characteristics of the skin and on the integrity of skin barrier. The advantages of noninvasive technology are not only lack of destruction, but the possibility of discerning subclinical effects not observed by the eye. A description of these techniques and a review of the literature is provided.
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