Biogenesis of tail-anchored proteins

N. Borgese, S. Brambillasca, P. Soffientini, M. Yabal, M. Makarow

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

A group of integral membrane proteins, known as C-tail anchored, is defined by the presence of a cytosolic N-terminal domain that is anchored to the phospholipid bilayer by a single segment of hydrophobic amino acids close to the C-terminus. The mode of insertion into membranes of these proteins, many of which play key roles in fundamental intracellular processes, is obligatorily post-translational, is highly specific and may be subject to regulatory processes that modulate the protein's function. Recent work has demonstrated that tail-anchored proteins translocate their C-termini across the endoplasmic reticulum membrane by a mechanism different from that used for Sec61-dependent post-translational signal-peptide-driven translocation. Here we summarize recent results on the insertion of tail-anchored proteins and discuss possible mechanisms that could be involved.

Original languageEnglish
Pages (from-to)1238-1242
Number of pages5
JournalBiochemical Society Transactions
Volume31
Issue number6
Publication statusPublished - Dec 2003

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Membrane Proteins
Proteins
Protein Sorting Signals
Endoplasmic Reticulum
Phospholipids
Membranes
Amino Acids

Keywords

  • Endoplasmic reticulum
  • Membrane protein insertion
  • Protein targeting
  • Protein translocation
  • Sec61 translocon
  • Transmembrane domain

ASJC Scopus subject areas

  • Biochemistry

Cite this

Borgese, N., Brambillasca, S., Soffientini, P., Yabal, M., & Makarow, M. (2003). Biogenesis of tail-anchored proteins. Biochemical Society Transactions, 31(6), 1238-1242.

Biogenesis of tail-anchored proteins. / Borgese, N.; Brambillasca, S.; Soffientini, P.; Yabal, M.; Makarow, M.

In: Biochemical Society Transactions, Vol. 31, No. 6, 12.2003, p. 1238-1242.

Research output: Contribution to journalArticle

Borgese, N, Brambillasca, S, Soffientini, P, Yabal, M & Makarow, M 2003, 'Biogenesis of tail-anchored proteins', Biochemical Society Transactions, vol. 31, no. 6, pp. 1238-1242.
Borgese N, Brambillasca S, Soffientini P, Yabal M, Makarow M. Biogenesis of tail-anchored proteins. Biochemical Society Transactions. 2003 Dec;31(6):1238-1242.
Borgese, N. ; Brambillasca, S. ; Soffientini, P. ; Yabal, M. ; Makarow, M. / Biogenesis of tail-anchored proteins. In: Biochemical Society Transactions. 2003 ; Vol. 31, No. 6. pp. 1238-1242.
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