BIOINCOMPATIBILITA DEL TRATTAMENTO EMODIALITICO

Translated title of the contribution: Bioincompatibility of peritoneal dialysis

C. Libetta, T. Rampino, B. Guida, R. Giulivo, S. Federico, W. De Simone, G. Cavaliere, M. Punzi, F. Evangelista, B. Memoli

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously demonstrated in patients dialyzed with cuprophane membranes an increased production of both interleukin 6 (IL-6) and Beta 2-microglobulin (β2-m) by cultured peripheral blood mononuclear cells (PBMC). No study has addressed this issue in patients undergoing CAPD, a treatment characterized by absence of blood interaction with bio(in)compatible membranes. To investigate the systemic inflammatory events secondary to CAPD, we evaluated the release of both IL-6 and β2-m by PBMC obtained from peritonitis-free CAPD patients. These measurements were compared with those obtained in hemodialysis (HD) patients, uremic non-dialyzed patients (UR) and healthy control subjects (C). In CAPD, IL-6 production from PBMC was markedly increased with respect to the control value (600.7 ± 104.3 vs 14.2 ± 3.6 pg/3 x 106 PBMC/24 hr, respectively) but was similar to the value found in HD patients (664.4 ± 138.9 pg/3 x 106 PBMC/24 hr). Similarly a striking increase in β2-m PBMC release was detected in CAPD with respect to C (10.1 ± 1.6 vs 0.063 ± 0.013 μg/3 x 106 PBMC/24 hr, respectively). In conclusion, CAPD induces per se activation of PBMC with enhanced release of IL-6 and β2-m. These systemic inflammatory events, being comparable with those occurring in HD, indicate that CAPD may not be different from HD in terms of bioincompatibility.

Translated title of the contributionBioincompatibility of peritoneal dialysis
Original languageItalian
Pages (from-to)47-52
Number of pages6
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume13
Issue number1
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Nephrology

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