BIOINCOMPATIBILITA DEL TRATTAMENTO EMODIALITICO

Translated title of the contribution: Bioincompatibility of peritoneal dialysis

C. Libetta, T. Rampino, B. Guida, R. Giulivo, S. Federico, W. De Simone, G. Cavaliere, M. Punzi, F. Evangelista, B. Memoli

Research output: Contribution to journalArticle

Abstract

We have previously demonstrated in patients dialyzed with cuprophane membranes an increased production of both interleukin 6 (IL-6) and Beta 2-microglobulin (β2-m) by cultured peripheral blood mononuclear cells (PBMC). No study has addressed this issue in patients undergoing CAPD, a treatment characterized by absence of blood interaction with bio(in)compatible membranes. To investigate the systemic inflammatory events secondary to CAPD, we evaluated the release of both IL-6 and β2-m by PBMC obtained from peritonitis-free CAPD patients. These measurements were compared with those obtained in hemodialysis (HD) patients, uremic non-dialyzed patients (UR) and healthy control subjects (C). In CAPD, IL-6 production from PBMC was markedly increased with respect to the control value (600.7 ± 104.3 vs 14.2 ± 3.6 pg/3 x 106 PBMC/24 hr, respectively) but was similar to the value found in HD patients (664.4 ± 138.9 pg/3 x 106 PBMC/24 hr). Similarly a striking increase in β2-m PBMC release was detected in CAPD with respect to C (10.1 ± 1.6 vs 0.063 ± 0.013 μg/3 x 106 PBMC/24 hr, respectively). In conclusion, CAPD induces per se activation of PBMC with enhanced release of IL-6 and β2-m. These systemic inflammatory events, being comparable with those occurring in HD, indicate that CAPD may not be different from HD in terms of bioincompatibility.

Original languageItalian
Pages (from-to)47-52
Number of pages6
JournalGiornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia
Volume13
Issue number1
Publication statusPublished - 1996

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ASJC Scopus subject areas

  • Nephrology

Cite this

Libetta, C., Rampino, T., Guida, B., Giulivo, R., Federico, S., De Simone, W., Cavaliere, G., Punzi, M., Evangelista, F., & Memoli, B. (1996). BIOINCOMPATIBILITA DEL TRATTAMENTO EMODIALITICO. Giornale italiano di nefrologia : organo ufficiale della Società italiana di nefrologia, 13(1), 47-52.