Bioinformatics in mass spectrometry data analysis for proteomics studies

Simone Cristoni, Luigi Rossi Bernardi

Research output: Contribution to journalArticlepeer-review


Mass spectrometry is a technique widely employed for the identification and characterization of proteins. The role of bioinformatics is fundamental for the elaboration of mass spectrometry data due to the amount of data that this technique can produce. To process data efficiently, new software packages and algorithms are continuously being developed to improve protein identification and characterization in terms of high-throughput and statistical accuracy. However, many limitations exist concerning bioinformatics spectral data elaboration. This review aims to critically cover the recent and future developments of new bioinformatics approaches in mass spectrometry data analysis for proteomics studies.

Original languageEnglish
Pages (from-to)469-483
Number of pages15
JournalExpert Review of Proteomics
Issue number4
Publication statusPublished - 2004


  • Bioinformatics
  • ESI
  • ICAT
  • Liquid chromatography
  • Mass spectrometry
  • Peptides
  • Proteins
  • Proteomics
  • Tandem mass spectrometry

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Biotechnology


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