Bioinformatics prioritization of SNPs perturbing microRNA regulation of hematological malignancy-implicated genes

Hamid Ghaedi, Milad Bastami, Davood Zare-Abdollahi, Behnam Alipoor, Abolfazl Movafagh, Reza Mirfakhraie, Mir Davood Omrani, Andrea Masotti

Research output: Contribution to journalArticlepeer-review

Abstract

The contribution of microRNAs (miRNAs) to cancer has been extensively investigated and it became obvious that a strict regulation of miRNA-mRNA regulatory network is crucial for safeguarding cell health. Apart from the direct impact of miRNA dysregulation in cancer pathogenesis, genetic variations in miRNAs are likely to disrupt miRNA-target interaction. Indeed, many evidences suggested that SNPs within miRNA regulome are associated with the development of different hematological malignancies. However, a full catalog of SNPs within miRNAs target sites of genes relevant to hematopoiesis and hematological malignancies is still lacking. Accordingly, we aimed to systematically identify and characterize such SNPs and provide a prioritized list of most potentially disrupting SNPs. Although in the present study we did not address the functional significance of these potential disturbing variants, we believe that our compiled results will be valuable for researchers interested in determining the role of target-SNPs in the development of hematological malignancies.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
JournalGenomics
Volume106
Issue number6
DOIs
Publication statusPublished - Dec 1 2015

Keywords

  • Hematological malignancy
  • Leukemia
  • MicroRNA
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics

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