Bioinspired scaffolds for osteochondral regeneration

Silvia Lopa, Henning Madry

Research output: Contribution to journalArticle

Abstract

Osteochondral defects are difficult to treat because the articular cartilage and the subchondral bone have dissimilar characteristics and abilities to regenerate. Bioinspired scaffolds are designed to mimic structural and biological cues of the native osteochondral unit, supporting both cartilaginous and subchondral bone repair and the integration of the newly formed osteochondral matrix with the surrounding tissues. The aim of this review is to outline fundamental requirements and strategies for the development of biomimetic scaffolds reproducing the unique and multifaceted anatomical structure of the osteochondral unit. Recent progress in preclinical animal studies using bilayer and multilayer scaffolds, together with continuous gradient scaffolds will be discussed and placed in a translational perspective with data emerging from their clinical application to treat osteochondral defects in patients.

Original languageEnglish
Pages (from-to)2052-2076
Number of pages25
JournalTissue Engineering - Part A
Volume20
Issue number15-16
DOIs
Publication statusPublished - Aug 1 2014

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Biomedical Engineering
  • Biomaterials
  • Medicine(all)

Fingerprint Dive into the research topics of 'Bioinspired scaffolds for osteochondral regeneration'. Together they form a unique fingerprint.

  • Cite this