Biologic and clinical significance of cytokine production in B-cell malignancies.

M. Torcia, D. Aldinucci, A. M. Carossino, F. Imreh, F. Cozzolino

Research output: Contribution to journalArticlepeer-review

Abstract

Cytokines are a group of polypeptide hormones endowed with pleiotropic biological properties. Normal B lymphocytes produce a number of these factors that subserve important regulatory functions in the combined processes of proliferation and differentiation. Also neoplastic B cells can release cytokines and, simultaneously, respond to the same factors in an autocrine circuit that supports their malignant growth. In addition, tumor cells can make use of the factors released by normal cells, either spontaneously or under the influence of inductive signals from the neoplastic cells. Inappropriate or excessive release of cytokines may have an important role in the pathophysiology of some clinical features. Thus, neutralization of cytokine biologic activity in vivo could be a therapeutic strategy for treatment of human B-cell neoplasias.

Original languageEnglish
Pages (from-to)35-42
Number of pages8
JournalEuropean Journal of Haematology, Supplement
Volume51
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology

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