The conclusion of this brief report is that estradiol exercises a direct biological action on the fetal guinea pig uterus and this tissue is a model one for the study of estrogen and antiestrogen responses with respect to estrogen and progesterone receptors. The fetal uterus increased in length by a factor of 50 to 80 percent as compared with non-treated animals. Progesterone receptors were induced and stimulated so that they were 7 to 10 times more active. Retention of tritiated progesterone in the uterus was increased. Estradiol has a prolonged effect on progesterone receptor but it diminishes most significantly after birth. There are estradiol receptors in the ovaries which are stimulated by the administration of estradiol. Nafoxidin and tamoxifen, antiestrogen, also produce a ureterotrophic effect but these substances have only a very weak action on progesterone receptor. Estradiol has an inhibitory effect on its own receptor. Only a few specific progesterone receptors are found in other tissues (fetal lung, brain and heart) and they are not significantly stimulated by administering estradiol.
|Translated title of the contribution||Biological action of estrogens and anti-estrogens in the fetal uterus of guinea pig: uterotrophic effect and stimulation on progesterone receptors|
|Number of pages||2|
|Publication status||Published - 1980|
ASJC Scopus subject areas
- Pathology and Forensic Medicine