Biological actions of drugs affecting serotonin and eating.

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The present status of knowledge on drugs affecting food intake and presumably acting via a serotoninergic mechanism is reviewed. The mechanism of action of these drugs is analyzed at the neurochemical level. All the drugs, to various extents, inhibit the uptake of serotonin (5HT), increase the release of 5HT and decrease brain levels of 5HT and 5HIAA. However, the underlying mechanisms are not identical as exemplified by comparisons made with d-fenfluramine, d-norfenfluramine, fluoxetine, sertraline and paroxetine. An analysis of the role of 5HT in the inhibition of food intake reveals that only d-fenfluramine is inhibited by antiserotonin agents. The role of the different 5HT receptor-subtypes in this antagonism is discussed. More selective 5HT antagonists are needed to establish which 5HT receptor(s) controls food intake.

Original languageEnglish
JournalObesity Research
Volume3 Suppl 4
Publication statusPublished - Nov 1995

Fingerprint

Serotonin Agents
fenfluramine
serotonin
Fenfluramine
food intake
Eating
ingestion
drugs
Norfenfluramine
Pharmaceutical Preparations
Sertraline
Paroxetine
receptors
Fluoxetine
antagonists
mechanism of action
Serotonin
uptake mechanisms
brain
Brain

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

Cite this

Biological actions of drugs affecting serotonin and eating. / Garattini, S.

In: Obesity Research, Vol. 3 Suppl 4, 11.1995.

Research output: Contribution to journalArticle

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