Biological activities in the granules isolated from the mouse submaxillary gland

F. Pasquini, Anna Petris, G. Sbaraglia, R. Scopelliti, G. Cenci, L. Frati

Research output: Contribution to journalArticle

Abstract

Growth factors, proteins which specifically enhance the growth of target tissues, were found in the homogenate of submaxillary gland in various molecular forms, due to the association with an esteroproteolytic enzyme. Since it has not been stated if macromolecular complexes were due to a loss of cellular compartmentalization during homogenization, secretory granules were isolated from the gland homogenate and both enzymatic and hormonal activities on the various fractions of granules were determined. The results obtained indicate that growth factors and esteroprotease activity are associated in the same intracellular particles, suggesting a possible role of the enzyme in the maturation of native molecules of growth factors, as described for proinsulin-insulin conversion.

Original languageEnglish
Pages (from-to)233-236
Number of pages4
JournalExperimental Cell Research
Volume86
Issue number2
DOIs
Publication statusPublished - 1974

    Fingerprint

ASJC Scopus subject areas

  • Cell Biology

Cite this

Pasquini, F., Petris, A., Sbaraglia, G., Scopelliti, R., Cenci, G., & Frati, L. (1974). Biological activities in the granules isolated from the mouse submaxillary gland. Experimental Cell Research, 86(2), 233-236. https://doi.org/10.1016/0014-4827(74)90708-3