Biological activity of anastrozole in postmenopausal patients with advanced breast cancer: Effects on estrogens and bone metabolism

E. Bombardieri, E. Bajetta, A. Martinetti, N. Zilembo, P. Pozzi, I. La Torre, L. Ferrari, E. Seregni, R. Longarini, G. Salvucci

Research output: Contribution to journalArticle

Abstract

Background: To study the short-term biological effect of anastrozole on serum estrogens, androgens, 17-hydroxyprogesterone (17OH-PGR), gonadotrophins, sex hormone binding globulin (SHBG) and bone metabolism markers. Materials and methods: Thirty-four consecutive patients with advanced breast cancer received anastrozole 1 mg/day. Blood samples were taken before commencement of treatment and at 2, 4, 8 and 12 weeks during treatment to measure serum levels of estrogens (E 1, E 2 and E 1-S), androgens [androstenedione (Δ 4), dihydrotestosterone (DHT), testosterone (TST), free TST, dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S)], 17OH-PGR, SHBG and gonadotrophins. As an indicator of bone resorption, we measured serum levels of C-terminal telopeptide of type I collagen (ICTP) and the cross-linked N-telopeptide of type I collagen (NTx), and for osteoblastic activity, intact osteocalcin (BGP) and bone alkaline phosphatase (BAP). Results: After 2 weeks E 1 and E 1-S levels decreased on average by 56% (range 23.1-88.8%) and 75.8% (range 52.4-87.2%), respectively; E 2 decreased on average by 62% (range 31.4-89.6%). No significant changes were detected in levels of androgens of 17OH-PGR. There was a significant increase in gonadotrophins over time (P=0.0001 for both luteinizing hormone and follicle-stimulating hormone), and a significant decrease in SHBG (P=0.0001). A progressive significant increase in bone metabolism serum markers was detected in all patients: BAP, P=0.039; BGP, P=0.016; ICTP, P=0.0021; and NTx, P=0.0013. In particular, patients with bone metastases had a statistically significant increase of bone resorption markers (ICTP, P=0.0019; NTx, P=0.025) and borderline for bone formation markers. In patients without bone disease, BAP, BGP and ICTP remained unchanged, whereas serum NTx significantly increased (P=0.019). Conclusions: Anastrozole is a selective aromatase inhibitor as it does not modify serum levels of androgens and 17OH-PGR. In our experience no relationship was found in the short-term period between serum estrogen suppression and bone metabolism.

Original languageEnglish
Pages (from-to)1059-1066
Number of pages8
JournalAnnals of Oncology
Volume13
Issue number7
DOIs
Publication statusPublished - 2002

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Keywords

  • Androgens
  • Aromatase inhibitors
  • Bone metabolism markers
  • Breast cancer
  • Estrogens

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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