TY - JOUR
T1 - Biological activity of chitosan
T2 - ultrastructural study
AU - Muzzarelli, R.
AU - Baldassarre, V.
AU - Conto, F.
AU - Ferrara, P.
AU - Biagini, G.
AU - Gazzanelli, G.
AU - Vasi, V.
PY - 1988
Y1 - 1988
N2 - Reparative processes are reconstructive phenomena in which cellular elements and extracellular matrix glycoproteins interact to build the injured tissue. Biomaterials can be used to improve or stimulate reconstruction. In the present experimental investigation, tissue repair induced by chitosan, an 86.8% deacetylated poly(GlcNAc), was monitored by morphological analysis. To evaluate its biological role, chitosan was positioned in contact with dura mater or was used as a dura mater substitute. This polysaccharide, having structural characteristics similar to glycosaminoglycans, seems to mimic their functional behaviour. The inductive and stimulatory activity of chitosan on connective tissue-rebuilding is clearly demonstrated, and it is suggested that chitosan could be considered a primer on which a normal tissue architecture is organized.
AB - Reparative processes are reconstructive phenomena in which cellular elements and extracellular matrix glycoproteins interact to build the injured tissue. Biomaterials can be used to improve or stimulate reconstruction. In the present experimental investigation, tissue repair induced by chitosan, an 86.8% deacetylated poly(GlcNAc), was monitored by morphological analysis. To evaluate its biological role, chitosan was positioned in contact with dura mater or was used as a dura mater substitute. This polysaccharide, having structural characteristics similar to glycosaminoglycans, seems to mimic their functional behaviour. The inductive and stimulatory activity of chitosan on connective tissue-rebuilding is clearly demonstrated, and it is suggested that chitosan could be considered a primer on which a normal tissue architecture is organized.
KW - Chitosan
KW - extracellular matrix
KW - morphology
UR - http://www.scopus.com/inward/record.url?scp=0023897981&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023897981&partnerID=8YFLogxK
U2 - 10.1016/0142-9612(88)90092-0
DO - 10.1016/0142-9612(88)90092-0
M3 - Article
C2 - 3408796
AN - SCOPUS:0023897981
VL - 9
SP - 247
EP - 252
JO - Biomaterials
JF - Biomaterials
SN - 0142-9612
IS - 3
ER -