Biological and chemical changes in fluoroquinolone-associated tendinopathies: a systematic review

Domenico Rocco Bisaccia, Rocco Aicale, Domiziano Tarantino, Giuseppe M. Peretti, Nicola Maffulli

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: The present systematic review investigates the biological and chemical mechanisms that affect the health and structure of tendons following the use of fluoroquinolones (FQs). SOURCES OF DATA: A total of 12 articles were included, organized, and reported following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. AREAS OF AGREEMENT: Five mechanisms were identified: arrest of proliferation through a decreased activity of cyclin B, CDK-1, CHK-1, and increased PK-1; decrease tenocytes migration through decreased phosphorylation of FAK; decrease type I collagen metabolism through increased MMP-2; chelate effect on ions that influence epigenetics and several enzymes; fluoroquinolones-induced ROS (radical oxygen species) production in mitochondria. AREAS OF CONTROVERSY: There is no definite structure-damage relationship. The dose-effect relationship is unclear. GROWING POINTS: Knowing and defining the damage exerted by FQs plays a role in clinical practice, replacing FQs with other antibacterial drugs or using antioxidants to attenuate their pathological effects. AREAS TIMELY FOR DEVELOPING RESEARCH: Clinical and basic sciences studies for each FQs are necessary.

Original languageEnglish
Pages (from-to)39-49
Number of pages11
JournalBritish Medical Bulletin
Volume130
Issue number1
DOIs
Publication statusPublished - Jun 19 2019

Fingerprint

Tendinopathy
Fluoroquinolones
Cyclin B
Collagen Type I
Matrix Metalloproteinases
Epigenomics
Tendons
Meta-Analysis
Reactive Oxygen Species
Mitochondria
Antioxidants
Phosphorylation
Guidelines
Ions
Health
Enzymes
Research
Pharmaceutical Preparations

Keywords

  • achilles
  • fluoroquinolone
  • tendinopathy
  • tendon
  • tendon rupture

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Biological and chemical changes in fluoroquinolone-associated tendinopathies : a systematic review. / Bisaccia, Domenico Rocco; Aicale, Rocco; Tarantino, Domiziano; Peretti, Giuseppe M.; Maffulli, Nicola.

In: British Medical Bulletin, Vol. 130, No. 1, 19.06.2019, p. 39-49.

Research output: Contribution to journalArticle

Bisaccia, Domenico Rocco ; Aicale, Rocco ; Tarantino, Domiziano ; Peretti, Giuseppe M. ; Maffulli, Nicola. / Biological and chemical changes in fluoroquinolone-associated tendinopathies : a systematic review. In: British Medical Bulletin. 2019 ; Vol. 130, No. 1. pp. 39-49.
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