Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: Description of eight cases

A. Cantu-Rajnoldi, R. Invernizzi, A. Biondi, P. Banfi, A. Zoia, P. De Fazio, N. Polli

Research output: Contribution to journalArticle

Abstract

We describe eight patients (four children and four adults) with an acute lymphoblastic leukaemia (ALL) with cytoplasmic granules or inclusions. The incidence of this variant of acute leukaemia in our whole series of patients with ALL is 1.8%. The granules or inclusions were usually positive for aspecific esterases (ANAE) and/or acid phosphatase, and the immunophenotype was in all cases typical of a CALLA positive B-lineage ALL (CD10+, CD19+ and/or CD24+, DR+ TdT+, anti-T-, anti-My-, Slg-). In one paediatric case, CD33 was unusually coexpressed. Ultrastructural investigations were performed in one case and demonstrated large granules containing vesicles, usually membrane bound. In the majority of blast cells. In the two cases analysed, Ig heavy chain gene rearrangement was detected. In this series of patients prognosis was poor since three never achieved a complete remission, four relapsed and only one is still in first continuous remission.

Original languageEnglish
Pages (from-to)309-314
Number of pages6
JournalBritish Journal of Haematology
Volume73
Issue number3
Publication statusPublished - 1989

ASJC Scopus subject areas

  • Hematology

Fingerprint Dive into the research topics of 'Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: Description of eight cases'. Together they form a unique fingerprint.

  • Cite this

    Cantu-Rajnoldi, A., Invernizzi, R., Biondi, A., Banfi, P., Zoia, A., De Fazio, P., & Polli, N. (1989). Biological and clinical features of acute lymphoblastic leukaemia with cytoplasmic granules or inclusions: Description of eight cases. British Journal of Haematology, 73(3), 309-314.