Biological and clinical relevance of proliferative activity in inflammatory breast cancer

A. Paradiso, A. Mangia, G. Tortora, F. Schittulli, M. De Lena

Research output: Contribution to journalArticlepeer-review

Abstract

The hormone receptor status and proliferative activity characteristics of inflammatory breast cancer (IBC) were studied in a series of 46 patients. ER and PgR were measured by the DCC method and proliferative activity was by the 3H-thymidine autoradiographic labeling index (3H-Tdr-LI). Tumors were ER and PgR positive in 42% and 38% of cases, respectively, whereas median 3H-Tdr-LI was 3.8%. With regard to clinical aspects, overall survival (OS) was not affected by either ER status (36 cases) or 3H-Tdr-LI value (33 cases). On the contrary, PgR+ status was able to individualize women with a significantly higher probability of OS (X2 by long rank test, p = 0.03) after 35 months of follow-up. In the subgroup of 14 patients subjected to double biopsy performed before and after administration of primary polychemotherapy, the tumor proliferative activity variations were not related to clinical outcome.

Original languageEnglish
Pages (from-to)563-567
Number of pages5
JournalInternational Journal of Oncology
Volume6
Issue number3
Publication statusPublished - 1995

Keywords

  • inflammatory breast cancer
  • proliferative activity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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