The hormone receptor status and proliferative activity characteristics of inflammatory breast cancer (IBC) were studied in a series of 46 patients. ER and PgR were measured by the DCC method and proliferative activity was by the 3H-thymidine autoradiographic labeling index (3H-Tdr-LI). Tumors were ER and PgR positive in 42% and 38% of cases, respectively, whereas median 3H-Tdr-LI was 3.8%. With regard to clinical aspects, overall survival (OS) was not affected by either ER status (36 cases) or 3H-Tdr-LI value (33 cases). On the contrary, PgR+ status was able to individualize women with a significantly higher probability of OS (X2 by long rank test, p = 0.03) after 35 months of follow-up. In the subgroup of 14 patients subjected to double biopsy performed before and after administration of primary polychemotherapy, the tumor proliferative activity variations were not related to clinical outcome.
|Number of pages||5|
|Journal||International Journal of Oncology|
|Publication status||Published - 1995|
- inflammatory breast cancer
- proliferative activity
ASJC Scopus subject areas
- Cancer Research