TY - JOUR
T1 - Biological and clinical relevance of proliferative activity in inflammatory breast cancer
AU - Paradiso, A.
AU - Mangia, A.
AU - Tortora, G.
AU - Schittulli, F.
AU - De Lena, M.
PY - 1995
Y1 - 1995
N2 - The hormone receptor status and proliferative activity characteristics of inflammatory breast cancer (IBC) were studied in a series of 46 patients. ER and PgR were measured by the DCC method and proliferative activity was by the 3H-thymidine autoradiographic labeling index (3H-Tdr-LI). Tumors were ER and PgR positive in 42% and 38% of cases, respectively, whereas median 3H-Tdr-LI was 3.8%. With regard to clinical aspects, overall survival (OS) was not affected by either ER status (36 cases) or 3H-Tdr-LI value (33 cases). On the contrary, PgR+ status was able to individualize women with a significantly higher probability of OS (X2 by long rank test, p = 0.03) after 35 months of follow-up. In the subgroup of 14 patients subjected to double biopsy performed before and after administration of primary polychemotherapy, the tumor proliferative activity variations were not related to clinical outcome.
AB - The hormone receptor status and proliferative activity characteristics of inflammatory breast cancer (IBC) were studied in a series of 46 patients. ER and PgR were measured by the DCC method and proliferative activity was by the 3H-thymidine autoradiographic labeling index (3H-Tdr-LI). Tumors were ER and PgR positive in 42% and 38% of cases, respectively, whereas median 3H-Tdr-LI was 3.8%. With regard to clinical aspects, overall survival (OS) was not affected by either ER status (36 cases) or 3H-Tdr-LI value (33 cases). On the contrary, PgR+ status was able to individualize women with a significantly higher probability of OS (X2 by long rank test, p = 0.03) after 35 months of follow-up. In the subgroup of 14 patients subjected to double biopsy performed before and after administration of primary polychemotherapy, the tumor proliferative activity variations were not related to clinical outcome.
KW - inflammatory breast cancer
KW - proliferative activity
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M3 - Article
AN - SCOPUS:0028930576
VL - 6
SP - 563
EP - 567
JO - International Journal of Oncology
JF - International Journal of Oncology
SN - 1019-6439
IS - 3
ER -