Biological and clinical role of p73 in neuroblastoma

M. Romani, G. P. Tonini, B. Banelli, G. Allemanni, K. Mazzocco, P. Scaruffi, L. Boni, M. Ponzoni, G. Pagnan, L. Raffaghello, S. Ferrini, M. Croce, I. Casciano

Research output: Contribution to journalArticlepeer-review

Abstract

The p73 gene is a p53 homologue localized at 1p36.3, a chromosomal region frequently deleted in neuroblastoma. p73 was originally considered an oncosuppressor gene. However, it was soon realized that its mode of action did not resemble that of a classic anti-oncogene. The recent discovery of N-terminal truncated isoforms, with oncogenic properties, showed that p73 has a 'two in one' structure. Indeed, the full-length variants are strong inducers of apoptosis while the truncated isoforms inhibit the pro-apoptotic activity of p53 and of the full-length p73. This review summarizes some aspects of p73 biology with particular reference to its possible role in neuroblastoma.

Original languageEnglish
Pages (from-to)111-117
Number of pages7
JournalCancer Letters
Volume197
Issue number1-2
DOIs
Publication statusPublished - Jul 18 2003

Keywords

  • Apoptosis
  • Methylation
  • Neuroblastoma
  • p73
  • Tumor suppressor gene

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

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