Biological and clinical significance of plasma-cell acid phosphatase in multiple myeloma

P. Musto, D. Barbieri, A. Cuneo, R. Spanedda, G. Scapoli, M. Carotenuto, G. Castoldi

Research output: Contribution to journalArticlepeer-review


Acid phosphatase activity of plasma-cells (PAP) was studied in 69 patients affected by multiple myeloma (MM). A significant correlation between PAP score and some clinical and laboratory features (RCSR, 'residual' immunoglobulins, bone lesions, hemoglobin, bone-marrow plasma-cell percentage, renal failure, advanced clinical stage) was observed. Moreover, the average PAP activity prior to treatment as well as in relapse or progression of disease, was significantly higher when compared to stable partial or complete remission and 'smouldering' myeloma. Nevertheless, all patients with high number of 'flaming' plasma-cells showed a constantly low cytoenzymatic index. Finally, there were no relationships between PAP score and immunological class of M-component.

Original languageEnglish
Pages (from-to)6-12
Number of pages7
JournalItalian Journal of Medicine
Issue number1
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)


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