Biological and genetic determinants of atopy are predictors of immediate-type allergy to betalactams, in Spain

J. A. Cornejo-García, R. M. Guéant-Rodriguez, M. J. Torres, N. Blanca-Lopez, D. Tramoy, A. Romano, M. Blanca, J. L. Guéant

Research output: Contribution to journalArticlepeer-review

Abstract

Background Betalactam (BL) immediate-type allergy is influenced by environmental and genetic determinants, as illustrated by differences in worldwide prevalence and ethnicity from a same area and by associations with genes related to atopy. Aims To evaluate the association of atopy with BL allergy. Materials and methods We measured specific Immunoglobulin E (IgE) against prevalent allergens and genetic predictors of atopy, IL13, IL4, IL4RA, IL4, and TNFA, in 340 patients and 340 controls from South of Spain. Results Total IgE and IgE against mites were at higher concentration in patients. Patients with high total IgE and IgE against prevalent allergens had a slower decrease in BL IgE than nonatopic patients. IL4RA I50V and Q551R were associated with IgE against prevalent allergens and total IgE, respectively, and were also predictors of BL allergy. Conclusion Interacting determinants of atopy, total IgE, IgE against prevalent allergens, and IL4RA polymorphisms, contribute to the high prevalence of BL allergy in South of Spain.

Original languageEnglish
Pages (from-to)1181-1185
Number of pages5
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume67
Issue number9
DOIs
Publication statusPublished - Sep 2012

Keywords

  • atopy
  • betalactam allergy
  • house dust mite
  • IgE
  • polymorphisms

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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