Biological and pharmacological roles of N6-isopentenyladenosine: An emerging anticancer drug

Maurizio Bifulco, Anna M. Malfitano, Maria Chiara Proto, Antonietta Santoro, Maria Gabriella Caruso, Chiara Laezza

Research output: Contribution to journalArticle

Abstract

A common modification of eukaryotic and bacterial tRNAs is isopentenylation of the adenosine at position 37, with the formation of isopentenyladenosine. N6-Isopentenyladenosine plays a major role in posttranscriptional processes, including the function of mammalian selenocysteine tRNA. This molecule seems to have metabolic effects that, for its relationships with isoprenoid metabolism and its direct biological activities, affects mammalian cell cytoskeleton, proliferation and apoptosis. In addition, preliminary servation seems to indicate a possible use of N6-Isopentenyladenosine as anticancer drug.

Original languageEnglish
Pages (from-to)200-204
Number of pages5
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume8
Issue number2
DOIs
Publication statusPublished - Feb 2008

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Keywords

  • N6-Isopentenyladenosine; apoptosis; cancer

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Medicine
  • Pharmacology

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