Biological and structural characterization of a naturally inspired material engineered from elastin as a candidate for tissue engineering applications

Massimo Vassalli, Francesca Sbrana, Alessandro Laurita, Massimiliano Papi, Nora Bloise, Livia Visai, Brigida Bochicchio

Research output: Contribution to journalArticle

Abstract

The adoption of a biomimetic approach in the design and fabrication of innovative materials for biomedical applications is encountering a growing interest. In particular, new molecules are being engineered on the basis of proteins present in the extracellular matrix, such as fibronectin, collagen, or elastin. Following this approach scientists expect to be able not only to obtain materials with tailored mechanical properties but also to elicit specific biological responses inherited by the mimicked tissue. In the present work, a novel peptide, engineered starting from the sequence encoded by exon 28 of human tropoelastin, was characterized from a chemical, physical, and biological point of view. The obtained molecule was observed to aggregate at high temperatures, forming a material able to induce a biological effect similar to what elastin does in the physiological context. This material seems to be a good candidate to play a relevant role in future biomedical applications with special reference to vascular surgery.

Original languageEnglish
Pages (from-to)15898-15906
Number of pages9
JournalLangmuir
Volume29
Issue number51
DOIs
Publication statusPublished - Dec 23 2013

Fingerprint

elastin
Elastin
tissue engineering
Tissue engineering
biological effects
biomimetics
collagens
surgery
peptides
molecules
Tropoelastin
mechanical properties
proteins
fabrication
Molecules
Biomimetics
matrices
Fibronectins
Collagen
Surgery

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Biological and structural characterization of a naturally inspired material engineered from elastin as a candidate for tissue engineering applications. / Vassalli, Massimo; Sbrana, Francesca; Laurita, Alessandro; Papi, Massimiliano; Bloise, Nora; Visai, Livia; Bochicchio, Brigida.

In: Langmuir, Vol. 29, No. 51, 23.12.2013, p. 15898-15906.

Research output: Contribution to journalArticle

Vassalli, Massimo ; Sbrana, Francesca ; Laurita, Alessandro ; Papi, Massimiliano ; Bloise, Nora ; Visai, Livia ; Bochicchio, Brigida. / Biological and structural characterization of a naturally inspired material engineered from elastin as a candidate for tissue engineering applications. In: Langmuir. 2013 ; Vol. 29, No. 51. pp. 15898-15906.
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