Biological and synthetic conduits in peripheral nerve repair: A comparative experimental study

R. Giardino, N. N. Aldini, G. Perego, G. Cella, M. C. Maltarello, M. Fini, M. Rocca, G. Giavaresi

Research output: Contribution to journalArticle

Abstract

Two different types of conduits, one biological, obtained with homologous glutaraldehyde preserved vein segments and the other synthetic bioabsorbable, made with Poly [L-lactide-co-6-caprolactone], were evaluated as guides for nerve repair in alternative to autologous grafts in an experimental animal model. Under general anesthetic, the ischiatic nerve of a number Wistar rats was transacted to create a 1 cm gap, which was then repaired by means of the conduits or autologous grafts. Controls were performed at 1, 3 and 6 months; nerve regeneration was effective with both conduits, but the count of myelinated axons showed a significant difference between the synthetic and biological tubes (p

Original languageEnglish
Pages (from-to)225-230
Number of pages6
JournalInternational Journal of Artificial Organs
Volume18
Issue number4
Publication statusPublished - 1995

Keywords

  • Microsurgery
  • Nerve grafts
  • Nerve reconstruction
  • Nerve regeneration
  • Polylactic acid
  • Preserved vein

ASJC Scopus subject areas

  • Biophysics

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