Biological approaches to breast cancer prevention

A. Costa

Research output: Contribution to journalArticle

Abstract

Breast cancer prevention is one of the most challenging issues modern oncology is trying to address. Different strategies for risk avoidance, chemopreventive measures and chemosuppressive treatments are being investigated from both experimental and clinical points of view. Unfortunately, age - the main risk factor - is unavoidable. Data available on other potentially modifiable aspects such as diet, childbearing and hormone-related risk factors are controversial. 'Westernization' of lifestyle, fatty diet and late pregnancies combined with manipulation of sex hormones by oral contraceptives and oestrogen replacement therapy are likely to increase the risk of developing breast cancer. Chemoprevention denotes prevention of cancer by use of pharmacological agents to inhibit or reverse the process of carcinogenesis. Among the compounds proposed for breast cancer prevention, major research is being conducted on retinoids (particulary the synthetic molecule, 4-hydroxyphenil retinamide), selenium and difluoromethylornithine. Chemosuppression relates to the action of antioestrogens such as tamoxifen on the promotion of breast cancer in postmenopausal women. A careful evaluation of the cost/benefit ratio for proposed measures of breast cancer prevention are compulsory prior to any recommendation to the public.

Original languageEnglish
Pages (from-to)119-123
Number of pages5
JournalBreast
Volume1
Issue number3
DOIs
Publication statusPublished - 1992

Fingerprint

Breast Neoplasms
Diet
Eflornithine
Estrogen Replacement Therapy
Estrogen Receptor Modulators
Retinoids
Chemoprevention
Gonadal Steroid Hormones
Tamoxifen
Selenium
Oral Contraceptives
Cost-Benefit Analysis
Life Style
Carcinogenesis
Hormones
Pharmacology
Pregnancy
Research
Neoplasms
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynaecology

Cite this

Biological approaches to breast cancer prevention. / Costa, A.

In: Breast, Vol. 1, No. 3, 1992, p. 119-123.

Research output: Contribution to journalArticle

Costa, A. / Biological approaches to breast cancer prevention. In: Breast. 1992 ; Vol. 1, No. 3. pp. 119-123.
@article{90222e1d51b741aabaafbd2a59a12637,
title = "Biological approaches to breast cancer prevention",
abstract = "Breast cancer prevention is one of the most challenging issues modern oncology is trying to address. Different strategies for risk avoidance, chemopreventive measures and chemosuppressive treatments are being investigated from both experimental and clinical points of view. Unfortunately, age - the main risk factor - is unavoidable. Data available on other potentially modifiable aspects such as diet, childbearing and hormone-related risk factors are controversial. 'Westernization' of lifestyle, fatty diet and late pregnancies combined with manipulation of sex hormones by oral contraceptives and oestrogen replacement therapy are likely to increase the risk of developing breast cancer. Chemoprevention denotes prevention of cancer by use of pharmacological agents to inhibit or reverse the process of carcinogenesis. Among the compounds proposed for breast cancer prevention, major research is being conducted on retinoids (particulary the synthetic molecule, 4-hydroxyphenil retinamide), selenium and difluoromethylornithine. Chemosuppression relates to the action of antioestrogens such as tamoxifen on the promotion of breast cancer in postmenopausal women. A careful evaluation of the cost/benefit ratio for proposed measures of breast cancer prevention are compulsory prior to any recommendation to the public.",
author = "A. Costa",
year = "1992",
doi = "10.1016/0960-9776(92)90156-V",
language = "English",
volume = "1",
pages = "119--123",
journal = "Breast",
issn = "0960-9776",
publisher = "Churchill Livingstone",
number = "3",

}

TY - JOUR

T1 - Biological approaches to breast cancer prevention

AU - Costa, A.

PY - 1992

Y1 - 1992

N2 - Breast cancer prevention is one of the most challenging issues modern oncology is trying to address. Different strategies for risk avoidance, chemopreventive measures and chemosuppressive treatments are being investigated from both experimental and clinical points of view. Unfortunately, age - the main risk factor - is unavoidable. Data available on other potentially modifiable aspects such as diet, childbearing and hormone-related risk factors are controversial. 'Westernization' of lifestyle, fatty diet and late pregnancies combined with manipulation of sex hormones by oral contraceptives and oestrogen replacement therapy are likely to increase the risk of developing breast cancer. Chemoprevention denotes prevention of cancer by use of pharmacological agents to inhibit or reverse the process of carcinogenesis. Among the compounds proposed for breast cancer prevention, major research is being conducted on retinoids (particulary the synthetic molecule, 4-hydroxyphenil retinamide), selenium and difluoromethylornithine. Chemosuppression relates to the action of antioestrogens such as tamoxifen on the promotion of breast cancer in postmenopausal women. A careful evaluation of the cost/benefit ratio for proposed measures of breast cancer prevention are compulsory prior to any recommendation to the public.

AB - Breast cancer prevention is one of the most challenging issues modern oncology is trying to address. Different strategies for risk avoidance, chemopreventive measures and chemosuppressive treatments are being investigated from both experimental and clinical points of view. Unfortunately, age - the main risk factor - is unavoidable. Data available on other potentially modifiable aspects such as diet, childbearing and hormone-related risk factors are controversial. 'Westernization' of lifestyle, fatty diet and late pregnancies combined with manipulation of sex hormones by oral contraceptives and oestrogen replacement therapy are likely to increase the risk of developing breast cancer. Chemoprevention denotes prevention of cancer by use of pharmacological agents to inhibit or reverse the process of carcinogenesis. Among the compounds proposed for breast cancer prevention, major research is being conducted on retinoids (particulary the synthetic molecule, 4-hydroxyphenil retinamide), selenium and difluoromethylornithine. Chemosuppression relates to the action of antioestrogens such as tamoxifen on the promotion of breast cancer in postmenopausal women. A careful evaluation of the cost/benefit ratio for proposed measures of breast cancer prevention are compulsory prior to any recommendation to the public.

UR - http://www.scopus.com/inward/record.url?scp=44049112357&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44049112357&partnerID=8YFLogxK

U2 - 10.1016/0960-9776(92)90156-V

DO - 10.1016/0960-9776(92)90156-V

M3 - Article

AN - SCOPUS:44049112357

VL - 1

SP - 119

EP - 123

JO - Breast

JF - Breast

SN - 0960-9776

IS - 3

ER -