Aspetti biologici del carcinoma pancreatico

Translated title of the contribution: Biological aspects of pancreatic cancer

E. Tonel, A. Carbone, T. Scirelli, G. Bellone, G. Emanuelli

Research output: Contribution to journalArticle

Abstract

Pancreatic ductal carcinoma still is an aggressive disease with a fatal prognosis due to late diagnosis and resistance to pharmacological and surgical treatments. Molecular investigations of pancreatic cancer are complicated by the restricted accessibility of the organ for biopsies. However, recent studies have indicated that pancreatic cancer is a multi-stage process resulting from the accumulation of genetic changes in the somatic DNA of normal cells. These molecular alterations, including overexpression of receptor-ligand systems, oncogene activation and loss of tumour suppressor genes, leads to a profound disturbance in cell cycle regulation and continuous growth. The molecular findings are now integrated in a pancreatic tumour progression model, with genetically and morphological defined precursor lesions. However, it remains unclear whether the initial target cells of this cancer develop from ductal or acinar cells. This review will present recent emerging questions on the biology of pancreatic cancer with particular emphasis on the cell origin and tumour microenvironment.

Original languageItalian
Pages (from-to)87-94
Number of pages8
JournalMinerva Medica
Volume96
Issue number2
Publication statusPublished - 2005

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Pancreatic Neoplasms
Pancreatic Ductal Carcinoma
Cellular Microenvironment
Tumor Microenvironment
Acinar Cells
Delayed Diagnosis
Tumor Suppressor Genes
Oncogenes
Neoplasms
Cell Cycle
Pharmacology
Ligands
Biopsy
DNA
Growth
Therapeutics

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Tonel, E., Carbone, A., Scirelli, T., Bellone, G., & Emanuelli, G. (2005). Aspetti biologici del carcinoma pancreatico. Minerva Medica, 96(2), 87-94.

Aspetti biologici del carcinoma pancreatico. / Tonel, E.; Carbone, A.; Scirelli, T.; Bellone, G.; Emanuelli, G.

In: Minerva Medica, Vol. 96, No. 2, 2005, p. 87-94.

Research output: Contribution to journalArticle

Tonel, E, Carbone, A, Scirelli, T, Bellone, G & Emanuelli, G 2005, 'Aspetti biologici del carcinoma pancreatico', Minerva Medica, vol. 96, no. 2, pp. 87-94.
Tonel E, Carbone A, Scirelli T, Bellone G, Emanuelli G. Aspetti biologici del carcinoma pancreatico. Minerva Medica. 2005;96(2):87-94.
Tonel, E. ; Carbone, A. ; Scirelli, T. ; Bellone, G. ; Emanuelli, G. / Aspetti biologici del carcinoma pancreatico. In: Minerva Medica. 2005 ; Vol. 96, No. 2. pp. 87-94.
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