Biological assessment of the bone-screw interface after insertion of uncoated and hydroxyapatite-coated pedicular screws in the osteopenic sheep

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Abstract

The sheep seems to be a promising model of osteoporosis and biomaterial osteointegration in osteopenic bone. The long-term ovariectomized sheep model was used for the biological investigation of bone healing around uncoated and hydroxyapatite (HA)-coated pedicle screws in osteopenic bone. Four sheep were ovariectomized and four sheep were sham-operated. Twenty-four months after surgery, the animals were implanted with uncoated and HA-coated stainless steel screws in the lumbar vertebral pedicles. Four months later, bone-to-implant contact, bone ingrowth, and bone hardness were measured around screws. Uncoated stainless steel presented significantly (p <0.0005) lower bone-to-implant contact in healthy and osteopenic bone compared with HA-coated stainless steel. HA significantly improved bone ingrowth in healthy bone (p <0.05) compared with uncoated stainless steel. Osteopenia significantly (p <0.05) reduced the area of bone ingrowth around the screw threads for both types of implants. In the inner thread area, bone microhardness significantly increased (p <0.05) in HA-coated surface versus uncoated for healthy and osteopenic bone. HA coating significantly enhances bone-to-implant contact also in osteopenic bone in comparison with uncoated stainless steel surfaces. Bone ingrowth and mineralization are ameliorated by the osteoconductive HA coating. However, osteopenia seems to greatly influence bone ingrowth processes around the implanted screws regardless of the characteristics of the material surface.

Original languageEnglish
Pages (from-to)176-183
Number of pages8
JournalJournal of Biomedical Materials Research - Part A
Volume66
Issue number1
Publication statusPublished - Jul 1 2003

Fingerprint

Bone Screws
Phthiraptera
Durapatite
Hydroxyapatite
Sheep
Bone
Bone and Bones
Stainless Steel
Stainless steel
Metabolic Bone Diseases
Screw threads
Physiologic Calcification
Coatings
Hardness
Biocompatible Materials

Keywords

  • Bone healing
  • Hydroxyapatite
  • Osteoporosis
  • Pedicular fixation
  • Sheep

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials

Cite this

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title = "Biological assessment of the bone-screw interface after insertion of uncoated and hydroxyapatite-coated pedicular screws in the osteopenic sheep",
abstract = "The sheep seems to be a promising model of osteoporosis and biomaterial osteointegration in osteopenic bone. The long-term ovariectomized sheep model was used for the biological investigation of bone healing around uncoated and hydroxyapatite (HA)-coated pedicle screws in osteopenic bone. Four sheep were ovariectomized and four sheep were sham-operated. Twenty-four months after surgery, the animals were implanted with uncoated and HA-coated stainless steel screws in the lumbar vertebral pedicles. Four months later, bone-to-implant contact, bone ingrowth, and bone hardness were measured around screws. Uncoated stainless steel presented significantly (p <0.0005) lower bone-to-implant contact in healthy and osteopenic bone compared with HA-coated stainless steel. HA significantly improved bone ingrowth in healthy bone (p <0.05) compared with uncoated stainless steel. Osteopenia significantly (p <0.05) reduced the area of bone ingrowth around the screw threads for both types of implants. In the inner thread area, bone microhardness significantly increased (p <0.05) in HA-coated surface versus uncoated for healthy and osteopenic bone. HA coating significantly enhances bone-to-implant contact also in osteopenic bone in comparison with uncoated stainless steel surfaces. Bone ingrowth and mineralization are ameliorated by the osteoconductive HA coating. However, osteopenia seems to greatly influence bone ingrowth processes around the implanted screws regardless of the characteristics of the material surface.",
keywords = "Bone healing, Hydroxyapatite, Osteoporosis, Pedicular fixation, Sheep",
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AU - Greggi, T.

AU - Martini, L.

AU - Nicoli Aldini, N.

AU - Parisini, P.

AU - Giardino, R.

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