Abstract
| Original language | English |
|---|---|
| Journal | Psychoneuroendocrinology |
| Volume | 125 |
| DOIs | |
| Publication status | E-pub ahead of print - Dec 5 2020 |
Keywords
- Biomarkers
- Childhood maltreatment
- Early life stress
- Epigenetics
- Gene expression
- Major depressive disorder (MDD)
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Biological correlates of early life stressful events in major depressive disorder. / Silva, R.C.; Maffioletti, E.; Gennarelli, M.; Baune, B.T.; Minelli, A.
In: Psychoneuroendocrinology, Vol. 125, 05.12.2020.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Biological correlates of early life stressful events in major depressive disorder
AU - Silva, R.C.
AU - Maffioletti, E.
AU - Gennarelli, M.
AU - Baune, B.T.
AU - Minelli, A.
N1 - Export Date: 11 February 2021 CODEN: PSYCD Correspondence Address: Minelli, A.; Department of Molecular and Translational Medicine, Viale Europa, 11, Italy; email: alessandra.minelli@unibs.it Funding text 1: None. References: Allen, L., Dwivedi, Y., MicroRNA mediators of early life stress vulnerability to depression and suicidal behavior (2020) Mol. Psychiatry, 25, pp. 308-320; Appel, K., Schwahn, C., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., Stender, J., Grabe, H.J., Moderation of adult depression by a polymorphism in the FKBP5 gene and childhood physical abuse in the general population (2011) Neuropsychopharmacology, 36, pp. 1982-1991; Archer, J.A., Hutchison, I.L., Dorudi, S., Stansfeld, S.A., Korszun, A., Interrelationship of depression, stress and inflammation in cancer patients: a preliminary study (2012) J. Affect. Disord., 143, pp. 39-46; Baldwin, J.R., Arseneault, L., Caspi, A., Fisher, H.L., Moffitt, T.E., Odgers, C.L., Pariante, C., Danese, A., Childhood victimization and inflammation in young adulthood: a genetically sensitive cohort study (2018) Brain Behav. Immun., 67, pp. 211-217; Banny, A.M., Cicchetti, D., Rogosch, F.A., Oshri, A., Crick, N.R., Vulnerability to depression: a moderated mediation model of the roles of child maltreatment, peer victimization, and serotonin transporter linked polymorphic region genetic variation among children from low socioeconomic status backgrounds (2013) Dev. Psychopathol., 25, pp. 599-614; Baumeister, D., Akhtar, R., Ciufolini, S., Pariante, C.M., Mondelli, V., Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-α (2016) Mol. Psychiatry, 21, pp. 642-649; Beck, D.A., Koenig, H.G., Beck, J.S., Depression (1998) Clin. Geriatr. Med., 14, pp. 765-786; Bersani, F.S., Wolkowitz, O.M., Lindqvist, D., Yehuda, R., Flory, J., Bierer, L.M., Makotine, I., Mellon, S.H., Global arginine bioavailability, a marker of nitric oxide synthetic capacity, is decreased in PTSD and correlated with symptom severity and markers of inflammation (2016) Brain Behav. Immun., 52, pp. 153-160; Border, R., Johnson, E.C., Evans, L.M., Smolen, A., Berley, N., Sullivan, P.F., Keller, M.C., No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples (2019) Am. J. Psychiatry, 176, pp. 376-387; Bower, J.E., Kuhlman, K.R., Ganz, P.A., Irwin, M.R., Crespi, C.M., Cole, S.W., Childhood maltreatment and monocyte gene expression among women with breast cancer (2020) Brain Behav. Immun., 88, pp. 396-402; Bücker, J., Fries, G.R., Kapczinski, F., Post, R.M., Yatham, L.N., Vianna, P., Bogo Chies, J.A., Kauer-Sant'Anna, M., Brain-derived neurotrophic factor and inflammatory markers in school-aged children with early trauma (2015) Acta Psychiatr. Scand., 131, pp. 360-368; Buss, C., Pruessner, J.C., Mayberg, H., Mletzko, T., Nemeroff, C., Heim, C., Larger amygdala volumes after childhood trauma associated with depression and cortisol response to psychosocial stress in adulthood (2012) Eur. J. Psychotraumatol., 3, p. 19556; Bustamante, A.C., Aiello, A.E., Guffanti, G., Galea, S., Wildman, D.E., Uddin, M., FKBP5 DNA methylation does not mediate the association between childhood maltreatment and depression symptom severity in the Detroit Neighborhood Health Study (2018) J. Psychiatr. Res., 96, pp. 39-48; Campbell, J.A., Farmer, G.C., Nguyen-Rodriguez, S., Walker, R., Egede, L., Relationship between individual categories of adverse childhood experience and diabetes in adulthood in a sample of US adults: Does it differ by gender? (2018) J. Diabetes Complicat., 32, pp. 139-143; Caspi, A., Sugden, K., Moffitt, T.E., Taylor, A., Craig, I.W., Harrington, H., McClay, J., Poulton, R., Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene (2003) Science, 301, pp. 386-389; Chmielewska, N., Szyndler, J., Maciejak, P., Płaźnik, A., Epigenetic mechanisms of stress and depression (2019) Psychiatr. Pol., 53, pp. 1413-1428; Coohey, C., Gender differences in internalizing problems among sexually abused early adolescents (2010) Child Abuse Negl., 34, pp. 856-862; Crozier, J.C., Wang, L., Huettel, S.A., De Bellis, M.D., Neural correlates of cognitive and affective processing in maltreated youth with posttraumatic stress symptoms: does gender matter? (2014) Dev. Psychopathol., 26, pp. 491-513; Culverhouse, R.C., Saccone, N.L., Horton, A.C., Ma, Y., Anstey, K.J., Banaschewski, T., Burmeister, M., Bierut, L.J., Collaborative meta-analysis finds no evidence of a strong interaction between stress and 5-HTTLPR genotype contributing to the development of depression (2018) Mol. Psychiatry, 23, pp. 133-142; Curran, E., Adamson, G., Rosato, M., De Cock, P., Leavey, G., Profiles of childhood trauma and psychopathology: US National Epidemiologic Survey (2018) Soc. Psychiatry Psychiatr. Epidemiol., 53, pp. 1207-1219; D'Souza, S., Thompson, J.M.D., Slykerman, R., Marlow, G., Wall, C., Murphy, R., Ferguson, L.R., Waldie, K.E., Environmental and genetic determinants of childhood depression: the roles of DAT1 and the antenatal environment (2016) J. Affect. Disord., 197, pp. 151-158; Dalvie, S., Maihofer, A.X., Coleman, J.R.I., Bradley, B., Breen, G., Brick, L.A., Chen, C.-Y., Nievergelt, C.M., Genomic influences on self-reported childhood maltreatment (2020) Transl. Psychiatry, 10, p. 38; Danese, A., Moffitt, T.E., Harrington, H., Milne, B.J., Polanczyk, G., Pariante, C.M., Poulton, R., Caspi, A., Adverse childhood experiences and adult risk factors for age-related disease: depression, inflammation, and clustering of metabolic risk markers (2009) Arch. Pediatr. Adolesc. Med., 163, pp. 1135-1143; Danese, A., Moffitt, T.E., Pariante, C.M., Ambler, A., Poulton, R., Caspi, A., Elevated inflammation levels in depressed adults with a history of childhood maltreatment (2008) Arch. Gen. Psychiatry, 65, pp. 409-415; de Punder, K., Entringer, S., Heim, C., Deuter, C.E., Otte, C., Wingenfeld, K., Kuehl, L.K., Inflammatory measures in depressed patients with and without a history of adverse childhood experiences (2018) Front. Psychiatry, 9, p. 610; Eisenberg, D.T.A., Mackillop, J., Modi, M., Beauchemin, J., Dang, D., Lisman, S.A., Lum, J.K., Wilson, D.S., Examining impulsivity as an endophenotype using a behavioral approach: a DRD2 TaqI A and DRD4 48-bp VNTR association study (2007) Behav. Brain Funct., 3, p. 2; Fan, H., Sun, X., Guo, W., Zhong, A., Niu, W., Zhao, L., Dai, Y., Lu, J., Differential expression of microRNA in peripheral blood mononuclear cells as specific biomarker for major depressive disorder patients (2014) J. Psychiatr. Res., 59, pp. 45-52; Farrell, C., Doolin, K., O’ Leary, N., Jairaj, C., Roddy, D., Tozzi, L., Morris, D., O'Keane, V., DNA methylation differences at the glucocorticoid receptor gene in depression are related to functional alterations in hypothalamic-pituitary-adrenal axis activity and to early life emotional abuse (2018) Psychiatry Res., 265, pp. 341-348; Ferrer, A., Costas, J., Labad, J., Salvat-Pujol, N., Segalàs, C., Urretavizcaya, M., Real, E., Soria, V., FKBP5 polymorphisms and hypothalamic-pituitary-adrenal axis negative feedback in major depression and obsessive-compulsive disorder (2018) J. Psychiatr. Res., 104, pp. 227-234; Fleurkens, P., van Minnen, A., Becker, E.S., van Oostrom, I., Speckens, A., Rinck, M., Vrijsen, J.N., Automatic approach-avoidance tendencies as a candidate intermediate phenotype for depression: associations with childhood trauma and the 5-HTTLPR transporter polymorphism (2018) PLoS One, 13; Frodl, T., Skokauskas, N., Frey, E.-M., Morris, D., Gill, M., Carballedo, A., BDNF Val66Met genotype interacts with childhood adversity and influences the formation of hippocampal subfields (2014) Hum. Brain Mapp., 35, pp. 5776-5783; Ganguly, P., Brenhouse, H.C., Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity (2015) Dev. Cogn. Neurosci., 11, pp. 18-30; Garfield, L., Mathews, H.L., Janusek, L.W., Inflammatory and epigenetic pathways for perinatal depression (2016) Biol. Res. Nurs., 18, pp. 331-343; Gerritsen, L., Milaneschi, Y., Vinkers, C.H., van Hemert, A.M., van Velzen, L., Schmaal, L., Penninx, B.W., HPA axis genes, and their interaction with childhood maltreatment, are related to cortisol levels and stress-related phenotypes (2017) Neuropsychopharmacology, 42, pp. 2446-2455; Gill, H., El-Halabi, S., Majeed, A., Gill, B., Lui, L.M.W., Mansur, R.B., Lipsitz, O., Rosenblat, J.D., The association between adverse childhood experiences and inflammation in patients with major depressive disorder: a systematic review (2020) J. Affect. Disord., 272, pp. 1-7; Grabe, H.J., Schwahn, C., Appel, K., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., Völzke, H., Childhood maltreatment, the corticotropin-releasing hormone receptor gene and adult depression in the general population (2010) Am. J. Med. Genet. B Neuropsychiatr. Genet., 153B, pp. 1483-1493; Grabe, H.J., Schwahn, C., Mahler, J., Schulz, A., Spitzer, C., Fenske, K., Appel, K., Freyberger, H.J., Moderation of adult depression by the serotonin transporter promoter variant (5-HTTLPR), childhood abuse and adult traumatic events in a general population sample (2012) Am. J. Med. Genet. B Neuropsychiatr. Genet., 159B, pp. 298-309; Grosse, L., Ambrée, O., Jörgens, S., Jawahar, M.C., Singhal, G., Stacey, D., Arolt, V., Baune, B.T., Cytokine levels in major depression are related to childhood trauma but not to recent stressors (2016) Psychoneuroendocrinology, 73, pp. 24-31; Grosse, L., Carvalho, L.A., Wijkhuijs, A.J.M., Bellingrath, S., Ruland, T., Ambrée, O., Alferink, J., Arolt, V., Clinical characteristics of inflammation-associated depression: monocyte gene expression is age-related in major depressive disorder (2015) Brain Behav. Immun., 44, pp. 48-56; Haeffel, G.J., Getchell, M., Koposov, R.A., Yrigollen, C.M., Deyoung, C.G., Klinteberg, B.A., Oreland, L., Grigorenko, E.L., Association between polymorphisms in the dopamine transporter gene and depression: evidence for a gene-environment interaction in a sample of juvenile detainees (2008) Psychol. Sci., 19, pp. 62-69; Han, T.J., Felger, J.C., Lee, A., Mister, D., Miller, A.H., Torres, M.A., Association of childhood trauma with fatigue, depression, stress, and inflammation in breast cancer patients undergoing radiotherapy (2016) Psychooncology, 25, pp. 187-193; Hannon, E., Lunnon, K., Schalkwyk, L., Mill, J., Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes (2015) Epigenetics, 10, pp. 1024-1032; Hasin, D.S., Sarvet, A.L., Meyers, J.L., Saha, T.D., Ruan, W.J., Stohl, M., Grant, B.F., Epidemiology of adult DSM-5 major depressive disorder and its specifiers in the United States (2018) JAMA Psychiatry, 75, pp. 336-346; Hayden, E.P., Klein, D.N., Dougherty, L.R., Olino, T.M., Laptook, R.S., Dyson, M.W., Bufferd, S.J., Singh, S.M., The dopamine D2 receptor gene and depressive and anxious symptoms in childhood: associations and evidence for gene-environment correlation and gene-environment interaction (2010) Psychiatr. Genet., 20, pp. 304-310; Heim, C., Bradley, B., Mletzko, T.C., Deveau, T.C., Musselman, D.L., Nemeroff, C.B., Ressler, K.J., Binder, E.B., Effect of childhood trauma on adult depression and neuroendocrine function: sex-specific moderation by CRH receptor 1 gene (2009) Front. Behav. Neurosci., 3, p. 41; Hing, B., Sathyaputri, L., Potash, J.B., A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder (2018) Am. J. Med. Genet. Part B Neuropsychiatr. Genet., 177, pp. 143-167; Holmes, L., Shutman, E., Chinaka, C., Deepika, K., Pelaez, L., Dabney, K.W., Aberrant epigenomic modulation of glucocorticoid receptor gene (NR3C1) in early life stress and major depressive disorder correlation: systematic review and quantitative evidence synthesis (2019) Int. J. Environ. Res. Public Health, p. 16; Hornung, O.P., Heim, C.M., Gene-environment interactions and intermediate phenotypes: early trauma and depression (2014) Front. Endocrinol., 5, p. 14; Hosang, G.M., Shiles, C., Tansey, K.E., McGuffin, P., Uher, R., Interaction between stress and the BDNF Val66Met polymorphism in depression: a systematic review and meta-analysis (2014) BMC Med., 12, p. 7; Hughes, K., Bellis, M.A., Hardcastle, K.A., Sethi, D., Butchart, A., Mikton, C., Jones, L., Dunne, M.P., The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis (2017) Lancet Public Heal., 2, pp. e356-e366; Infurna, M.R., Reichl, C., Parzer, P., Schimmenti, A., Bifulco, A., Kaess, M., Associations between depression and specific childhood experiences of abuse and neglect: a meta-analysis (2016) J. Affect. Disord., 190, pp. 47-55; Jawahar, M.C., Murgatroyd, C., Harrison, E.L., Baune, B.T., Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders (2015) Clin. Epigenet., 7, p. 122; Kang, H.-J., Kim, J.-M., Stewart, R., Kim, S.-Y., Bae, K.-Y., Kim, S.-W., Shin, I.-S., Yoon, J.-S., Association of SLC6A4 methylation with early adversity, characteristics and outcomes in depression (2013) Prog. Neuropsychopharmacol. Biol. Psychiatry, 44, pp. 23-28; Karg, K., Burmeister, M., Shedden, K., Sen, S., The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation (2011) Arch. Gen. Psychiatry, 68, pp. 444-454; Kaufman, J., Wymbs, N.F., Montalvo-Ortiz, J.L., Orr, C., Albaugh, M.D., Althoff, R., O'Loughlin, K., Hudziak, J., Methylation in OTX2 and related genes, maltreatment, and depression in children (2018) Neuropsychopharmacology, 43, pp. 2204-2211; Kaufman, J., Yang, B.-Z., Douglas-Palumberi, H., Grasso, D., Lipschitz, D., Houshyar, S., Krystal, J.H., Gelernter, J., Brain-derived neurotrophic factor–5-HTTLPR gene interactions and environmental modifiers of depression in children (2006) Biol. Psychiatry, 59, pp. 673-680; Kikusui, T., Kanbara, N., Ozaki, M., Hirayama, N., Ida, K., Tokita, M., Tanabe, N., Mogi, K., Early weaning increases anxiety via brain-derived neurotrophic factor signaling in the mouse prefrontal cortex (2019) Sci. Rep., 9, p. 3991; Kim, S., Watt, T., Ceballos, N., Sharma, S., Adverse childhood experiences and neuroinflammatory biomarkers-The role of sex (2019) Stress Health, 35, pp. 432-440; Klengel, T., Mehta, D., Anacker, C., Rex-Haffner, M., Pruessner, J.C., Pariante, C.M., Pace, T.W.W., Binder, E.B., Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions (2013) Nat. Neurosci., 16, pp. 33-41; Kraav, S.-L., Tolmunen, T., Kärkkäinen, O., Ruusunen, A., Viinamäki, H., Mäntyselkä, P., Koivumaa-Honkanen, H., Lehto, S.M., Decreased serum total cholesterol is associated with a history of childhood physical violence in depressed outpatients (2019) Psychiatry Res., 272, pp. 326-333; Kundakovic, M., Gudsnuk, K., Herbstman, J.B., Tang, D., Perera, F.P., Champagne, F.A., DNA methylation of BDNF as a biomarker of early-life adversity (2015) Proc. Natl. Acad. Sci. USA, 112, pp. 6807-6813; Labonté, B., Suderman, M., Maussion, G., Navaro, L., Yerko, V., Mahar, I., Bureau, A., Turecki, G., Genome-wide epigenetic regulation by early-life trauma (2012) Arch. Gen. Psychiatry, p. 69; Laterza, O.F., Lim, L., Garrett-Engele, P.W., Vlasakova, K., Muniappa, N., Tanaka, W.K., Johnson, J.M., Glaab, W.E., Plasma MicroRNAs as sensitive and specific biomarkers of tissue injury (2009) Clin. Chem., 55, pp. 1977-1983; Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A.F., Schmidt, M.H., Esser, G., Jennen-Steinmetz, C., Banaschewski, T., Interactive effects of corticotropin-releasing hormone receptor 1 gene and childhood adversity on depressive symptoms in young adults: findings from a longitudinal study (2013) Eur. Neuropsychopharmacol., 23, pp. 358-367; Lawford, B.R., Young, R., Noble, E.P., Kann, B., Ritchie, T., The D2 dopamine receptor (DRD2) gene is associated with co-morbid depression, anxiety and social dysfunction in untreated veterans with post-traumatic stress disorder (2006) Eur. Psychiatry, 21, pp. 180-185; Liang, Y., Ridzon, D., Wong, L., Chen, C., Characterization of microRNA expression profiles in normal human tissues (2007) BMC Genom., 8, p. 166; Liew, C.-C., Ma, J., Tang, H.-C., Zheng, R., Dempsey, A.A., The peripheral blood transcriptome dynamically reflects system wide biology: a potential diagnostic tool (2006) J. Lab. Clin. Med., 147, pp. 126-132; Lopizzo, N., Zonca, V., Cattane, N., Pariante, C.M., Cattaneo, A., miRNAs in depression vulnerability and resilience: novel targets for preventive strategies (2019) J. Neural Transm., 126, pp. 1241-1258; Lu, S., Peng, H., Wang, L., Vasish, S., Zhang, Y., Gao, W., Wu, W., Li, L., Elevated specific peripheral cytokines found in major depressive disorder patients with childhood trauma exposure: a cytokine antibody array analysis (2013) Compr. Psychiatry, 54, pp. 953-961; Lutz, P.E., Chay, M.A., Pacis, A., Chen, G.C., Aouabed, Z., Maffioletti, E., Théroux, J.F., Turecki, G., (2020), https://www.biorxiv.org/content/10.1101/501239v2, Non-CG methylation and multiple epigenetic layers associate child abuse with immune and small GTPase dysregulation. doi: https://doi.org/10.1101/501239; Lutz, P.-E., Gross, J.A., Dhir, S.K., Maussion, G., Yang, J., Bramoulle, A., Meaney, M.J., Turecki, G., Epigenetic regulation of the kappa opioid receptor by child abuse (2018) Biol. Psychiatry, 84, pp. 751-761; Lutz, P.-E., Tanti, A., Gasecka, A., Barnett-Burns, S., Kim, J.J., Zhou, Y., Chen, G.G., Turecki, G., Association of a history of child abuse with impaired myelination in the anterior cingulate cortex: convergent epigenetic, transcriptional, and morphological evidence (2017) Am. J. Psychiatry, 174, pp. 1185-1194; MacQueen, G., Frodl, T., The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research? (2011) Mol. Psychiatry, 16, pp. 252-264; Maffioletti, E., Tardito, D., Gennarelli, M., Bocchio-Chiavetto, L., Micro spies from the brain to the periphery: new clues from studies on microRNAs in neuropsychiatric disorders (2014) Front. Cell. Neurosci., 8, p. 75; Mandelli, L., Petrelli, C., Serretti, A., The role of specific early trauma in adult depression: a meta-analysis of published literature. Childhood trauma and adult depression (2015) Eur. Psychiatry, 30, pp. 665-680; McQuaid, R.J., McInnis, O.A., Stead, J.D., Matheson, K., Anisman, H., A paradoxical association of an oxytocin receptor gene polymorphism: early-life adversity and vulnerability to depression (2013) Front. Neurosci., 7, p. 128; Mehta, N.D., Stevens, J.S., Li, Z., Gillespie, C.F., Fani, N., Michopoulos, V., Felger, J.C., Inflammation, reward circuitry and symptoms of anhedonia and PTSD in trauma-exposed women (2020) Soc. Cogn. Affect. Neurosci, 15, pp. 1046-1055; Mikolas, P., Tozzi, L., Doolin, K., Farrell, C., O'Keane, V., Frodl, T., Effects of early life adversity and FKBP5 genotype on hippocampal subfields volume in major depression (2019) J. Affect. Disord., 252, pp. 152-159; Miller, G.E., Chen, E., Parker, K.J., Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms (2011) Psychol. Bull., 137, pp. 959-997; Miller, G.E., Cole, S.W., Clustering of depression and inflammation in adolescents previously exposed to childhood adversity (2012) Biol. Psychiatry, 72, pp. 34-40; Minelli, A., Magri, C., Giacopuzzi, E., Gennarelli, M., The effect of childhood trauma on blood transcriptome expression in major depressive disorder (2018) J. Psychiatr. Res., 104, pp. 50-54; Minelli, A., Zampieri, E., Sacco, C., Bazzanella, R., Mezzetti, N., Tessari, E., Barlati, S., Bortolomasi, M., Clinical efficacy of trauma-focused psychotherapies in treatment-resistant depression (TRD) in-patients: a randomized, controlled pilot-study (2019) Psychiatry Res., 273, pp. 567-574; Müller, N., Krause, D., Barth, R., Myint, A.-M., Weidinger, E., Stettinger, W., Zill, P., Schwarz, M.J., Childhood adversity and current stress are related to pro- and anti-inflammatory cytokines in major depression (2019) J. Affect. Disord., 253, pp. 270-276; Mullins, N., Power, R.A., Fisher, H.L., Hanscombe, K.B., Euesden, J., Iniesta, R., Levinson, D.F., Lewis, C.M., Polygenic interactions with environmental adversity in the aetiology of major depressive disorder (2016) Psychol. Med., 46, pp. 759-770; Munjiza, A., Kostic, M., Pesic, D., Gajic, M., Markovic, I., Tosevski, D.L., Higher concentration of interleukin 6 - a possible link between major depressive disorder and childhood abuse (2018) Psychiatry Res., 264, pp. 26-30; Nederhof, E., Bouma, E.M.C., Oldehinkel, A.J., Ormel, J., Interaction between childhood adversity, brain-derived neurotrophic factor val/met and serotonin transporter promoter polymorphism on depression: the TRAILS study (2010) Biol. Psychiatry, 68, pp. 209-212; Nelson, J., Klumparendt, A., Doebler, P., Ehring, T., Childhood maltreatment and characteristics of adult depression: meta-analysis (2017) Br. J. Psychiatry, 210, pp. 96-104; Nguyen, J.K., Thurston, R.C., Association of childhood trauma exposure with inflammatory biomarkers among midlife women (2020) J. Women's Health; Novo, P., Landin-Romero, R., Radua, J., Vicens, V., Fernandez, I., Garcia, F., Pomarol-Clotet, E., Amann, B.L., Eye movement desensitization and reprocessing therapy in subsyndromal bipolar patients with a history of traumatic events: a randomized, controlled pilot-study (2014) Psychiatry Res., 219, pp. 122-128; Olff, M., Frijling, J.L., Kubzansky, L.D., Bradley, B., Ellenbogen, M.A., Cardoso, C., Bartz, J.A., van Zuiden, M., The role of oxytocin in social bonding, stress regulation and mental health: an update on the moderating effects of context and interindividual differences (2013) Psychoneuroendocrinology, 38, pp. 1883-1894; Ostacoli, L., Carletto, S., Cavallo, M., Baldomir-Gago, P., Di Lorenzo, G., Fernandez, I., Hase, M., Hofmann, A., Comparison of eye movement desensitization reprocessing and cognitive behavioral therapy as adjunctive treatments for recurrent depression: the european depression EMDR network (EDEN) randomized controlled trial (2018) Front. Psychol., 9, p. 74; Özçürümez, G., Yurdakul, H.T., Terzi, Y., Direk, N., Eşsizoğlu, A., Şahin, F., No interaction between childhood maltreatment and serotonin transporter gene in recurrent major depressive disorder: a clinical sample (2019) Noro Psikiyatr. Ars., 56, pp. 110-114; Parade, S.H., Novick, A.M., Parent, J., Seifer, R., Klaver, S.J., Marsit, C.J., Gobin, A.P., Tyrka, A.R., Stress exposure and psychopathology alter methylation of the serotonin receptor 2A (HTR2A) gene in preschoolers (2017) Dev. Psychopathol., 29, pp. 1619-1626; Park, C., Rosenblat, J.D., Brietzke, E., Pan, Z., Lee, Y., Cao, B., Zuckerman, H., McIntyre, R.S., Stress, epigenetics and depression: a systematic review (2019) Neurosci. Biobehav. Rev., 102, pp. 139-152; Pedrotti Moreira, F., Wiener, C.D., Jansen, K., Portela, L.V., Lara, D.R., Souza, L.D., de, M., Oses, J.P., Childhood trauma and increased peripheral cytokines in young adults with major depressive: population-based study (2018) J. Neuroimmunol., 319, pp. 112-116; Peng, H., Zhu, Y., Strachan, E., Fowler, E., Bacus, T., Roy-Byrne, P., Goldberg, J., Zhao, J., Childhood trauma, DNA methylation of stress-related genes, and depression: findings from two monozygotic twin studies (2018) Psychosom. Med., 80, pp. 599-608; Penner-Goeke, S., Binder, E.B., Epigenetics and depression (2019) Dialogues Clin. Neurosci., 21, pp. 397-405; Perroud, N., Paoloni-Giacobino, A., Prada, P., Olié, E., Salzmann, A., Nicastro, R., Guillaume, S., Malafosse, A., Increased methylation of glucocorticoid receptor gene (NR3C1) in adults with a history of childhood maltreatment: a link with the severity and type of trauma (2011) Transl. Psychiatry, 1; Perroud, N., Zewdie, S., Stenz, L., Adouan, W., Bavamian, S., Prada, P., Nicastro, R., Dayer, A., Methylation of serotonin receptor 3A in ADHD, borderline personality, and bipolar disorders: link with severity of the disorders and childhood maltreatment (2016) Depress. Anxiety, 33, pp. 45-55; Peyrot, W.J., Milaneschi, Y., Abdellaoui, A., Sullivan, P.F., Hottenga, J.J., Boomsma, D.I., Penninx, B.W.J.H., Effect of polygenic risk scores on depression in childhood trauma (2014) Br. J. Psychiatry, 205, pp. 113-119; Peyrot, W.J., Van der Auwera, S., Milaneschi, Y., Dolan, C.V., Madden, P.A.F., Sullivan, P.F., Strohmaier, J., Penninx, B.W.J.H., Does childhood trauma moderate polygenic risk for depression? A meta-analysis of 5765 subjects from the psychiatric genomics consortium (2018) Biol. Psychiatry, 84, pp. 138-147; Piechaczek, C.E., Greimel, E., Feldmann, L., Pehl, V., Allgaier, A.-K., Frey, M., Freisleder, F.J., Schulte-Körne, G., Interactions between FKBP5 variation and environmental stressors in adolescent Major Depression (2019) Psychoneuroendocrinology, 106, pp. 28-37; Polanczyk, G., Caspi, A., Williams, B., Price, T.S., Danese, A., Sugden, K., Uher, R., Moffitt, T.E., Protective effect of CRHR1 gene variants on the development of adult depression following childhood maltreatment: replication and extension (2009) Arch. Gen. Psychiatry, 66, pp. 978-985; Powers, A., Dixon, H.D., Conneely, K., Gluck, R., Munoz, A., Rochat, C., Mendoza, H., Gillespie, C.F., The differential effects of PTSD, MDD, and dissociation on CRP in trauma-exposed women (2019) Compr. Psychiatry, 93, pp. 33-40; Ressler, K.J., Bradley, B., Mercer, K.B., Deveau, T.C., Smith, A.K., Gillespie, C.F., Nemeroff, C.B., Binder, E.B., Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms (2010) Am. J. Med., 153B, pp. 812-824; Roy, A., Gorodetsky, E., Yuan, Q., Goldman, D., Enoch, M.-A., Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide (2010) Neuropsychopharmacology, 35, pp. 1674-1683; Sadeh, N., Wolf, E.J., Logue, M.W., Hayes, J.P., Stone, A., Griffin, L.M., Schichman, S.A., Miller, M.W., Epigenetic variation at SKA2 predicts suicide phenotypes and internalizing psychopathology (2016) Depress. Anxiety, 33, pp. 308-315; Salas, J., van den Berk-Clark, C., Skiöld-Hanlin, S., Schneider, F.D., Scherrer, J.F., Adverse childhood experiences, depression, and cardiometabolic disease in a nationally representative sample (2019) J. Psychosom. Res., 127; Serpeloni, F., Radtke, K., de Assis, S.G., Henning, F., Nätt, D., Elbert, T., Grandmaternal stress during pregnancy and DNA methylation of the third generation: an epigenome-wide association study (2017) Transl. Psychiatry, 7; Skog, J., Würdinger, T., van Rijn, S., Meijer, D.H., Gainche, L., Sena-Esteves, M., Curry, W.T., Breakefield, X.O., Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers (2008) Nat. Cell Biol., 10, pp. 1470-1476; Spindola, L.M., Pan, P.M., Moretti, P.N., Ota, V.K., Santoro, M.L., Cogo-Moreira, H., Gadelha, A., Belangero, S.I., Gene expression in blood of children and adolescents: mediation between childhood maltreatment and major depressive disorder (2017) J. Psychiatr. Res., 92, pp. 24-30; Stanton, K.J., Denietolis, B., Goodwin, B.J., Dvir, Y., Childhood trauma and psychosis: an updated review (2020) Child Adolesc. Psychiatr. Clin. N. Am., 29, pp. 115-129; Suderman, M., Borghol, N., Pappas, J.J., Pinto Pereira, S.M., Pembrey, M., Hertzman, C., Power, C., Szyf, M., Childhood abuse is associated with methylation of multiple loci in adult DNA (2014) BMC Med. Genom., 7, p. 13; Sugden, K., Arseneault, L., Harrington, H., Moffitt, T.E., Williams, B., Caspi, A., Serotonin transporter gene moderates the development of emotional problems among children following bullying victimization (2010) J. Am. Acad. Child Adolesc. Psychiatry, 49, pp. 830-840; Sullivan, P.F., Fan, C., Perou, C.M., Evaluating the comparability of gene expression in blood and brain (2006) Am. J. Med., 141B, pp. 261-268; Swartz, J.R., Williamson, D.E., Hariri, A.R., Developmental change in amygdala reactivity during adolescence: effects of family history of depression and stressful life events (2015) Am. J. Psychiatry, 172, pp. 276-283; Tannous, J., Godlewska, B.R., Tirumalaraju, V., Soares, J.C., Cowen, P.J., Selvaraj, S., Stress, inflammation and hippocampal subfields in depression: a 7 Tesla MRI Study (2020) Transl. Psychiatry, 10, p. 78; Teicher, M.H., Anderson, C.M., Polcari, A., Childhood maltreatment is associated with reduced volume in the hippocampal subfields CA3, dentate gyrus, and subiculum (2012) Proc. Natl. Acad. Sci. USA, 109, pp. E563-E572; Thompson, R.J., Parker, K.J., Hallmayer, J.F., Waugh, C.E., Gotlib, I.H., Oxytocin receptor gene polymorphism (rs2254298) interacts with familial risk for psychopathology to predict symptoms of depression and anxiety in adolescent girls (2011) Psychoneuroendocrinology, 36, pp. 144-147; Toepfer, P., Heim, C., Entringer, S., Binder, E., Wadhwa, P., Buss, C., Oxytocin pathways in the intergenerational transmission of maternal early life stress (2017) Neurosci. Biobehav. Rev., 73, pp. 293-308; Tollenaar, M.S., Molendijk, M.L., Penninx, B.W.J.H., Milaneschi, Y., Antypa, N., The association of childhood maltreatment with depression and anxiety is not moderated by the oxytocin receptor gene (2017) Eur. Arch. Psychiatry Clin. Neurosci., 267, pp. 517-526; Torres-Berrío, A., Issler, O., Parise, E.M., Nestler, E.J., Unraveling the epigenetic landscape of depression: focus on early life stress (2019) Dialogues Clin. Neurosci., 21, pp. 341-357; Tozzi, L., Farrell, C., Booij, L., Doolin, K., Nemoda, Z., Szyf, M., Pomares, F.B., Frodl, T., Epigenetic changes of FKBP5 as a link connecting genetic and environmental risk factors with structural and functional brain changes in major depression (2018) Neuropsychopharmacology, 43, pp. 1138-1145; Trivedi, M.H., Rush, A.J., Wisniewski, S.R., Nierenberg, A.A., Warden, D., Ritz, L., Norquist, G., STAR*D Study Team, Evaluation of outcomes with citalopram for depression using measurement-based care in STAR*D: implications for clinical practice (2006) Am. J. Psychiatry, 163, pp. 28-40; Tyrka, A.R., Parade, S.H., Welch, E.S., Ridout, K.K., Price, L.H., Marsit, C., Philip, N.S., Carpenter, L.L., Methylation of the leukocyte glucocorticoid receptor gene promoter in adults: associations with early adversity and depressive, anxiety and substance-use disorders (2016) Transl. Psychiatry, 6; Tyrka, Audrey, R., Ridout, K.K., Parade, S.H., Childhood adversity and epigenetic regulation of glucocorticoid signaling genes: associations in children and adults (2016) Dev. Psychopathol., 28, pp. 1319-1331; Van der Auwera, S., Peyrot, W.J., Milaneschi, Y., Hertel, J., Baune, B., Breen, G., Byrne, E., Grabe, H., Genome-wide gene-environment interaction in depression: a systematic evaluation of candidate genes (2018) Am. J. Med. Genet. Part B Neuropsychiatr. Genet., 177, pp. 40-49; Vinkers, C.H., Joëls, M., Milaneschi, Y., Gerritsen, L., Kahn, R.S., Penninx, B.W.J.H., Boks, M.P.M., Mineralocorticoid receptor haplotypes sex-dependently moderate depression susceptibility following childhood maltreatment (2015) Psychoneuroendocrinology, 54, pp. 90-102; Walsh, K., Basu, A., Werner, E., Lee, S., Feng, T., Osborne, L.M., Rainford, A., Monk, C., Associations among child abuse, depression, and interleukin-6 in pregnant adolescents: paradoxical findings (2016) Psychosom. Med., 78, pp. 920-930; Wang, Q., Shelton, R.C., Dwivedi, Y., Interaction between early-life stress and FKBP5 gene variants in major depressive disorder and post-traumatic stress disorder: a systematic review and meta-analysis (2018) J. Affect. Disord., 225, pp. 422-428; Watkeys, O.J., Kremerskothen, K., Quidé, Y., Fullerton, J.M., Green, M.J., Glucocorticoid receptor gene (NR3C1) DNA methylation in association with trauma, psychopathology, transcript expression, or genotypic variation: a systematic review (2018) Neurosci. Biobehav. Rev., 95, pp. 85-122; Weaver, I.C.G., Cervoni, N., Champagne, F.A., D'Alessio, A.C., Sharma, S., Seckl, J.R., Dymov, S., Meaney, M.J., Epigenetic programming by maternal behavior (2004) Nat. Neurosci., 7, pp. 847-854; Weder, N., Zhang, H., Jensen, K., Yang, B.Z., Simen, A., Jackowski, A., Lipschitz, D., Kaufman, J., Child abuse, depression, and methylation in genes involved with stress, neural plasticity, and brain circuitry (2014) J. Am. Acad. Child Adolesc. Psychiatry, 53 (417–424.e5); White, J.D., Kaffman, A., The moderating effects of sex on consequences of childhood maltreatment: from clinical studies to animal models (2019) Front. Neurosci., 13, p. 1082; White, M.G., Bogdan, R., Fisher, P.M., Muñoz, K.E., Williamson, D.E., Hariri, A.R., FKBP5 and emotional neglect interact to predict individual differences in amygdala reactivity (2012) Genes. Brain. Behav., 11, pp. 869-878; Wray, N.R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E.M., Abdellaoui, A., Adams, M.J., Sullivan, P.F., Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression (2018) Nat. Genet., pp. 668-681; Xiong, L.-L., Xue, L.-L., Al-Hawwas, M., Huang, J., Niu, R.-Z., Tan, Y.-X., Xu, Y., Wang, T.-H., Single-nucleotide polymorphism screening and RNA sequencing of key messenger RNAs associated with neonatal hypoxic-ischemia brain damage (2020) Neural Regen. Res., 15, pp. 86-95; Zeugmann, S., Buehrsch, N., Bajbouj, M., Heuser, I., Anghelescu, I., Quante, A., Childhood maltreatment and adult proinflammatory status in patients with major depression (2013) Psychiatr. Danub., 25, pp. 227-235
PY - 2020/12/5
Y1 - 2020/12/5
N2 - Major depressive disorder (MDD) is the most common psychiatric disorder and responds for important psychosocial consequences. Stressful life events, especially early life stress (ELS), contribute to an increased probability to develop MDD, leading in particular to severe and chronic manifestation and unfavorable treatment outcome. The association between ELS and MDD seems to have biological bases, consisting in dysregulations occurring at different levels. The aim of this narrative review is to propose an overview of the literature ranging from genetic, epigenetic, expression and protein to neuroimaging correlates underlying this relationship. A search on Pubmed of studies assessing biological correlates of ELS in MDD development, focusing on human studies conducted in both peripheral and brain tissues, was performed. Evidence indicated that the hypothalamic-pituitary-adrenal (HPA) axis and the serotonergic, dopaminergic, neurotrophin and oxytocin systems might play a role in the mediation between ELS and MDD. The most consistent results were found for genetic and epigenetic studies and indicated a joint involvement of the systems mentioned. Expression studies are less numerous and point to an involvement of stress-related systems. Concerning protein studies, the main mediators are markers related to the inflammatory and immune systems. Neuroimaging studies aiming at evaluating brain alterations connecting ELS and MDD in relation to biomarkers indicated the hippocampus, the amygdala and the frontal cortex as important anatomical mediators. These findings can build the bases for future research and clinical interventions; indeed, the clarification of biological mechanisms mediating the relationship between ELS and MDD can lead to new and individualized preventive and therapeutic possibilities. © 2020 Elsevier Ltd
AB - Major depressive disorder (MDD) is the most common psychiatric disorder and responds for important psychosocial consequences. Stressful life events, especially early life stress (ELS), contribute to an increased probability to develop MDD, leading in particular to severe and chronic manifestation and unfavorable treatment outcome. The association between ELS and MDD seems to have biological bases, consisting in dysregulations occurring at different levels. The aim of this narrative review is to propose an overview of the literature ranging from genetic, epigenetic, expression and protein to neuroimaging correlates underlying this relationship. A search on Pubmed of studies assessing biological correlates of ELS in MDD development, focusing on human studies conducted in both peripheral and brain tissues, was performed. Evidence indicated that the hypothalamic-pituitary-adrenal (HPA) axis and the serotonergic, dopaminergic, neurotrophin and oxytocin systems might play a role in the mediation between ELS and MDD. The most consistent results were found for genetic and epigenetic studies and indicated a joint involvement of the systems mentioned. Expression studies are less numerous and point to an involvement of stress-related systems. Concerning protein studies, the main mediators are markers related to the inflammatory and immune systems. Neuroimaging studies aiming at evaluating brain alterations connecting ELS and MDD in relation to biomarkers indicated the hippocampus, the amygdala and the frontal cortex as important anatomical mediators. These findings can build the bases for future research and clinical interventions; indeed, the clarification of biological mechanisms mediating the relationship between ELS and MDD can lead to new and individualized preventive and therapeutic possibilities. © 2020 Elsevier Ltd
KW - Biomarkers
KW - Childhood maltreatment
KW - Early life stress
KW - Epigenetics
KW - Gene expression
KW - Major depressive disorder (MDD)
U2 - 10.1016/j.psyneuen.2020.105103
DO - 10.1016/j.psyneuen.2020.105103
M3 - Article
VL - 125
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -