Biological correlation between HER-2/neu and proliferative activity in human breast cancer

S. Tommasi, A. Paradiso, A. Mangia, A. Barletta, G. Simone, D. J. Slamon, M. De Lena

Research output: Contribution to journalArticle

Abstract

HER-2neu alterations (amplification and overxpression), proliferative activity (3H-Thymidine-Labeling Index, 3H-Tdr-LI) and tumor ploidy (flow-cytometry) were analyzed in a human breast cancer series. Overexpressed tumors showed a significantly higher median 3H-Tdr-LI than normally expressed (p=0.04), as also did amplified/overexpressed with respect to non-amplified/normally expressed (p<0.04). These differences were confirmed only in N- primary tumors. In fact, high expressed cases demonstrated a median 3H-Tdr-LI of 5.5% with respect to 1.9% for low expressed cases (p=0.04) and amplified/overexpressed had a 3H-Tdr-LI of 9% with respect to 2% for non amplified/low expressed (p=0.009). HER-2/neu alterations were not correlated with tumor DNA content.

Original languageEnglish
Pages (from-to)1395-1400
Number of pages6
JournalAnticancer Research
Volume11
Issue number4
Publication statusPublished - 1991

Keywords

  • Breast cancer
  • HER-2/neu
  • Oncogene
  • Proliferative activity

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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