Valutazione della dose biologicamente efficace (BED) in brachiterapia ginecologica: Trattamento LDR versus frazionamento HDR, dipendenza dai parametri radiobiologici, ottimizzazione del trattamento

Translated title of the contribution: Biological effective dose evaluation in gynaecological brachytherapy: LDR and HDR treatments, dependence on radiobiological parameters, and treatment optimisation

C. Bianchi, F. Botta, L. Conte, P. Vanoli, L. Cerizza

Research output: Contribution to journalArticle

Abstract

Purpose. This study was undertaken to compare the biological efficacy of different high-dose-rate (HDR) and low-dose-rate (LDR) treatments of gynaecological lesions, to identify the causes of possible nonuniformity and to optimise treatment through customised calculation. Materials and methods. The study considered 110 patients treated between 2001 and 2006 with external beam radiation therapy and/or brachytherapy with either LDR (afterloader Selectron, 137Cs) or HDR (afterloader microSelectron Classic, 192Ir). The treatments were compared in terms of biologically effective dose (BED) to the tumour and to the rectum (linear-quadratic model) by using statistical tests for comparisons between independent samples. Results. The difference between the two treatments was statistically significant in one case only. However, within each technique, we identified considerable nonuniformity in therapeutic efficacy due to differences in fractionation schemes and overall treatment time. To solve this problem, we created a Microsoft Excel spreadsheet allowing calculation of the optimal treatment for each patient: best efficacy (BED tumour) without exceeding toxicity threshold (BED rectum). Conclusions. The efficacy of a treatment may vary as a result of several factors. Customised radiobiological evaluation is a useful adjunct to clinical evaluation in planning equivalent treatments that satisfy all dosimetric constraints.

Translated title of the contributionBiological effective dose evaluation in gynaecological brachytherapy: LDR and HDR treatments, dependence on radiobiological parameters, and treatment optimisation
Original languageItalian
Pages (from-to)1068-1078
Number of pages11
JournalRadiologia Medica
Volume113
Issue number7
DOIs
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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