Biological effects of metal degradation in hip arthroplasties.

Research output: Contribution to journalArticle

Abstract

Metals and metal alloys are the most used materials in orthopedic implants. The focus is on total hip arthroplasty (THA) that, though well tolerated, may be associated with local and remote adverse effects in the medium-long term. This review aims to summarize data on the biological consequences of the metal implant degradation that have been attributed predominantly to metal-on-metal (MoM) THA. Local responses to metals consist of a broad clinical spectrum ranging from small asymptomatic tissue lesions to severe destruction of bone and soft tissues, which are designated as metallosis, adverse reactions to metal debris (ARMD), aseptic lymphocytic vasculitis associated lesion (ALVAL), and pseudotumors. In addition, the dissemination of metal particles and ions throughout the body has been associated with systemic adverse effects, including organ toxicity, cancerogenesis, teratogenicity, and immunotoxicity. As proved by the multitude of studies in this field, metal degradation may increase safety issues associated with THA, especially with MoM hip systems. Data collection regarding local, systemic and long-term effects plays an essential role to better define any safety risks and to generate scientifically based recommendations.
Original languageEnglish
Pages (from-to)170-193
Number of pages24
JournalCritical Reviews in Toxicology
Volume48
Issue number2
DOIs
Publication statusPublished - Feb 2018

Fingerprint

Arthroplasty
Hip
Metals
Degradation
Tissue
Safety
Orthopedics
Debris
Vasculitis
Toxicity
Bone
Ions

Keywords

  • Total joint arthroplasty
  • corrosion
  • local adverse effects
  • metal toxicity
  • systemic adverse effects
  • wear

Cite this

Biological effects of metal degradation in hip arthroplasties. / Granchi, Donatella; Savarino, Lucia Maria; Ciapetti, Gabriela; Baldini, Nicola.

In: Critical Reviews in Toxicology, Vol. 48, No. 2, 02.2018, p. 170-193.

Research output: Contribution to journalArticle

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