Biological effects of off-pump vs. on-pump coronary artery surgery: Focus on inflammation, hemostasis and oxidative stress

Paolo Biglioli, Aldo Cannata, Francesco Alamanni, Moreno Naliato, Massimo Porqueddu, Marco Zanobini, Elena Tremoli, Alessandro Parolari

Research output: Contribution to journalArticlepeer-review


Cardiopulmonary bypass (CPB) has been recognized as a cause of complex systemic inflammatory response, which significantly contributes to several adverse postoperative complications. In the last few years, off-pump coronary artery bypass grafting has gained widespread diffusion as an alternative technique to conventional on-pump coronary artery bypass grafting. Surgeons supporting off-pump surgery state that the avoidance of the CPB and myocardial ischemia-reperfusion significantly reduces the postoperative systemic inflammatory response and other biological derangements and, possibly, may improve the clinical outcomes. We review, here, the available evidence concerning possible differences between off-pump and on-pump procedures in terms of inflammation, hemostasis and oxidative stress. Consistent differences in the involvement of these systems are observed, but they are limited to the final steps of the surgical procedures and the early hours after. These findings suggest that the global surgical trauma may be as important, or even more, as the CPB in terms of systemic inflammatory and coagulation-fibrinolytic pathway activation. Further studies are needed in order to confirm this hypothesis.

Original languageEnglish
Pages (from-to)260-269
Number of pages10
JournalEuropean Journal of Cardio-thoracic Surgery
Issue number2
Publication statusPublished - Aug 1 2003


  • Beating heart surgery
  • Cardiopulmonary bypass
  • Coronary surgery
  • Hemostasis
  • Inflammation
  • Oxidative stress

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery


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