Biological effects of tissue modulations in wound healing

M. Fini, G. Morrone, R. Giardino, G. Ferioli, M. Mattioli-Belmonte, S. Amati, C. Tietz, G. Biagini, M. M. Tappa, G. Ricotti

Research output: Contribution to journalArticlepeer-review


The reactive and reparative capacity of injured tissue when treated with either Pulsed Electromagnetic Fields (PEMF's)or with immunomodulator drugs (Prostaglandin E2 and Thymopentin) was evaluated. A morphological and quantitative evaluation was made of the interactions and the interferences on the structural stages of tissue repair processes. When PEMF's were used the time required for new tissue to completely cover the wound was 26 days after surgery, instead of 30 days for control conditions or for treatment with PGE, or Thymopentin. PEMF's showed accelerated healing process. Bath PGE, and Thymopentin should be considered, in association with other drugs, in an attempt to strengthen the various immunomodulative phases of the reconstitution of injured tissue.

Original languageEnglish
Pages (from-to)85-102
Number of pages18
JournalJournal of Bioactive and Compatible Polymers
Issue number2
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Materials Chemistry
  • Polymers and Plastics


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