Biological heterogeneity of major depressive disorder: Indications by sleep EEG and TRH stimulation test findings

Luigi Pugnetti, Silvio Scarone, Franccesca Bramhilla

Research output: Contribution to journalArticlepeer-review

Abstract

A group of 27 patients with definite (n = 20) or probable (n = 7) RDC major depressive disorder underwent 2 sleep EEGs and 1 TRH test while in a drug-free depressive phase. A short mean REM latency (<60 min) identified 55.5% of major depressives while added use of blunted TSH responses (delta max. <5 μU/ml) increased that percentage by 11 %. When patients were subdivided into RDC endogenous and nonendogenous, mean REM latency and global depression scores distinguished the 2 groups, while delta TSH did not. A short mean REM latency identified endogenous depression with 80% specificity and 76% sensitivity. The combination of REM latency and delta TSH reduced the specificity to 60%, and therefore cannot be recommended for differentiating endogenous from nonendogenous depression.

Original languageEnglish
Pages (from-to)124-129
Number of pages6
JournalNeuropsychobiology
Volume17
Issue number3
DOIs
Publication statusPublished - 1987

Keywords

  • Diagnosis
  • Heterogeneity
  • Major depressive disorder
  • Sleep EEG
  • TRH stimulation test

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)
  • Psychology(all)

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