Biological indices predictive of survival in 519 Italian terminally ill cancer patients

Marco Maltoni, Marco Pirovano, Oriana Nanni, Mauro Marinari, Monica Indelli, Attilio Gramazio, Edmondo Terzoli, Massimo Luzzani, Filippo De Marinis, Augusto Caraceni, Roberto Labianca

Research output: Contribution to journalArticle

Abstract

The knowledge of prognostic factors capable of subdividing cancer patients into groups having homogeneous survival times is useful even in very advanced stages of illness. This prospective multicenter study assessed these prognostic factors in 530 terminal patients with solid tumors who were undergoing only palliative care. Thirteen hematological and urinary parameters were assessed on admission and every 28 days thereafter. In 519 assessable patients with a median survival of 32 days, six biological parameters demonstrated a statistically significant predictive prognosis. A poor prognosis was predicted by high total white blood count (WBC) (P <0.0001), high neutrophil percentage (P <0.0001), low lymphocyte percentage (P <0.0001), low serum albumin level (P = 0.0015), low pseudocholinesterase level (P <0.0001), and high proteinuria (P = 0.0064). Multiple regression analysis showed that only WBC, lymphocyte percentage and pseudocholinesterase level were independent predictors of survival. The individualization of biological parameters having an independent prognostic capacity is a useful step in the attempt to identify subsets of patients with a homogeneous prognosis. The biological factors needed are easily detected by means of a simple blood test and do not require invasive operations on patients who are already debilitated.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Pain and Symptom Management
Volume13
Issue number1
Publication statusPublished - Jan 1997

Fingerprint

Terminally Ill
Survival
Pseudocholinesterase
Neoplasms
Lymphocyte Count
Biological Factors
Hematologic Tests
Palliative Care
Proteinuria
Serum Albumin
Multicenter Studies
Neutrophils
Regression Analysis
Prospective Studies
Lymphocytes

Keywords

  • Laboratory parameters
  • prognostic factors
  • survival
  • terminal cancer patients

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine
  • Clinical Neurology
  • Neurology
  • Nursing(all)

Cite this

Maltoni, M., Pirovano, M., Nanni, O., Marinari, M., Indelli, M., Gramazio, A., ... Labianca, R. (1997). Biological indices predictive of survival in 519 Italian terminally ill cancer patients. Journal of Pain and Symptom Management, 13(1), 1-9.

Biological indices predictive of survival in 519 Italian terminally ill cancer patients. / Maltoni, Marco; Pirovano, Marco; Nanni, Oriana; Marinari, Mauro; Indelli, Monica; Gramazio, Attilio; Terzoli, Edmondo; Luzzani, Massimo; De Marinis, Filippo; Caraceni, Augusto; Labianca, Roberto.

In: Journal of Pain and Symptom Management, Vol. 13, No. 1, 01.1997, p. 1-9.

Research output: Contribution to journalArticle

Maltoni, M, Pirovano, M, Nanni, O, Marinari, M, Indelli, M, Gramazio, A, Terzoli, E, Luzzani, M, De Marinis, F, Caraceni, A & Labianca, R 1997, 'Biological indices predictive of survival in 519 Italian terminally ill cancer patients', Journal of Pain and Symptom Management, vol. 13, no. 1, pp. 1-9.
Maltoni, Marco ; Pirovano, Marco ; Nanni, Oriana ; Marinari, Mauro ; Indelli, Monica ; Gramazio, Attilio ; Terzoli, Edmondo ; Luzzani, Massimo ; De Marinis, Filippo ; Caraceni, Augusto ; Labianca, Roberto. / Biological indices predictive of survival in 519 Italian terminally ill cancer patients. In: Journal of Pain and Symptom Management. 1997 ; Vol. 13, No. 1. pp. 1-9.
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