Abstract
Trans, trans-muconic acid in the urine has been considered for many years a valid biomarker of occupational exposure to benzene. Our study covered a population of workers exposed to low occupational levels of benzene. Biological monitoring has been performed on 371 males working in 4 different divisions of an oil refining plant. We measured urinary concentrations of t,t-muconic acid at the beginning and at the end of the work shift. Since it is not allowed to smoke during work shift, the biological results would have not been significantly influenced by this habit. The mean urinary excretion of t,t-muconic acid, both at the beginning (76,32 μg/g creat) and at the end of the work shift (112,52 μg/g creat.) were similar to the one measured in non-exposed population. These data confirms the effectiveness of preventive measures adopted in order to minimize the occupational exposure of workers employed in different oil refining processes. However, it is important to point out that, in every different divisions examined, the mean urinary concentrations of t,t-muconic acid at the end of the work shift resulted significantly higher than at the beginning of the shift. This observation could be due to the effective exposure to benzene, even at low concentration, in the workplace. In conclusion our data suggest that, even in the case of a low professional exposure to benzene, the urinary t,t-muconic acid is a very sensitive marker able to show minimal occupational exposure.
| Original language | Italian |
|---|---|
| Pages (from-to) | 28-29 |
| Number of pages | 2 |
| Journal | Giornale Italiano di Medicina del Lavoro ed Ergonomia |
| Volume | 28 |
| Issue number | 3 SUPPL. |
| Publication status | Published - Jul 2006 |
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ASJC Scopus subject areas
- Public Health, Environmental and Occupational Health
- Rehabilitation
Cite this
Il monitoraggio biologico dell'esposizione a benzene : Significato del dosaggio dell'acido t,t-muconico urinario in una popolazione di lavoratori esposti a bassi livelli ambientali di benzene. / Taino, Giuseppe; Fabris, F.; Brena, L.; Marinoni, A.; Ferrari, M.; Imbriani, M.
In: Giornale Italiano di Medicina del Lavoro ed Ergonomia, Vol. 28, No. 3 SUPPL., 07.2006, p. 28-29.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Il monitoraggio biologico dell'esposizione a benzene
T2 - Significato del dosaggio dell'acido t,t-muconico urinario in una popolazione di lavoratori esposti a bassi livelli ambientali di benzene
AU - Taino, Giuseppe
AU - Fabris, F.
AU - Brena, L.
AU - Marinoni, A.
AU - Ferrari, M.
AU - Imbriani, M.
PY - 2006/7
Y1 - 2006/7
N2 - Trans, trans-muconic acid in the urine has been considered for many years a valid biomarker of occupational exposure to benzene. Our study covered a population of workers exposed to low occupational levels of benzene. Biological monitoring has been performed on 371 males working in 4 different divisions of an oil refining plant. We measured urinary concentrations of t,t-muconic acid at the beginning and at the end of the work shift. Since it is not allowed to smoke during work shift, the biological results would have not been significantly influenced by this habit. The mean urinary excretion of t,t-muconic acid, both at the beginning (76,32 μg/g creat) and at the end of the work shift (112,52 μg/g creat.) were similar to the one measured in non-exposed population. These data confirms the effectiveness of preventive measures adopted in order to minimize the occupational exposure of workers employed in different oil refining processes. However, it is important to point out that, in every different divisions examined, the mean urinary concentrations of t,t-muconic acid at the end of the work shift resulted significantly higher than at the beginning of the shift. This observation could be due to the effective exposure to benzene, even at low concentration, in the workplace. In conclusion our data suggest that, even in the case of a low professional exposure to benzene, the urinary t,t-muconic acid is a very sensitive marker able to show minimal occupational exposure.
AB - Trans, trans-muconic acid in the urine has been considered for many years a valid biomarker of occupational exposure to benzene. Our study covered a population of workers exposed to low occupational levels of benzene. Biological monitoring has been performed on 371 males working in 4 different divisions of an oil refining plant. We measured urinary concentrations of t,t-muconic acid at the beginning and at the end of the work shift. Since it is not allowed to smoke during work shift, the biological results would have not been significantly influenced by this habit. The mean urinary excretion of t,t-muconic acid, both at the beginning (76,32 μg/g creat) and at the end of the work shift (112,52 μg/g creat.) were similar to the one measured in non-exposed population. These data confirms the effectiveness of preventive measures adopted in order to minimize the occupational exposure of workers employed in different oil refining processes. However, it is important to point out that, in every different divisions examined, the mean urinary concentrations of t,t-muconic acid at the end of the work shift resulted significantly higher than at the beginning of the shift. This observation could be due to the effective exposure to benzene, even at low concentration, in the workplace. In conclusion our data suggest that, even in the case of a low professional exposure to benzene, the urinary t,t-muconic acid is a very sensitive marker able to show minimal occupational exposure.
KW - Benzene
KW - Biological monitoring
KW - t,t-muconic acid
UR - http://www.scopus.com/inward/record.url?scp=33846593801&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33846593801&partnerID=8YFLogxK
M3 - Articolo
AN - SCOPUS:33846593801
VL - 28
SP - 28
EP - 29
JO - Giornale Italiano di Medicina del Lavoro ed Ergonomia
JF - Giornale Italiano di Medicina del Lavoro ed Ergonomia
SN - 1592-7830
IS - 3 SUPPL.
ER -