Biological monitoring of Italian soldiers deployed in Iraq. Results of the SIGNUM project

Claudia Bolognesi, Lucia Migliore, Florigio Lista, Sergio Caroli, Marina Patriarca, Roberta De Angelis, Riccardo Capocaccia, Sergio Amadori, Alessandra Pulliero, Cristina Balia, Renato Colognato, Vincenzo La Gioia, Stefano Bonassi, Alberto Izzotti

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Leukemia/lymphoma cases reported in 2001 among United Nation soldiers or peacekeepers deployed to the Balkans aroused alert on the exposure to depleted uranium. Recent epidemiological studies carried out in different European countries among peacekeepers who served in the Balkans failed to demonstrate a higher than expected risk of all cancers but, mostly due to their limitations in size and follow up time, leave open the debate on health risk of depleted uranium. The aim of SIGNUM (Study of the Genotoxic Impact in Military Units) was to identify potential genotoxic risk associated with the exposure to depleted uranium or other pollutants in the Italian Army military personnel deployed in Iraq. Methods: Blood and urine samples were collected before and after the deployment from 981 Italian soldiers operating in Iraq in 2004-2005. As, Cd, Mo, Ni, Pb, U, V, W, and Zr were determined in urine and serum. DNA-adducts, 8-hydroxy-2'-deoxyguanine and micronuclei frequency were evaluated in blood lymphocytes. Three different genetic polymorphisms, GSTM1, XRCC1, OGG1 were analyzed. Results: Significant T0-. T1 reduction in the total concentration of uranium, increases for Cd, Mo, Ni, Zr, and decreases for As, Pb, W, and V in urine and plasma were observed. Increases in oxidative alterations and in micronuclei frequency, included in the range of values of non-occupationally exposed populations, were observed at the end of the period of employment. Conclusions: Our results did not detect any toxicologically relevant variation of DNA-damage biomarkers related to the deployment in the operational theater.

Original languageEnglish
Pages (from-to)24-32
Number of pages9
JournalInternational Journal of Hygiene and Environmental Health
Volume219
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Iraq
Uranium
Environmental Monitoring
Military Personnel
Balkan Peninsula
Urine
DNA Adducts
United Nations
Genetic Polymorphisms
DNA Damage
Epidemiologic Studies
Lymphoma
Leukemia
Biomarkers
Lymphocytes
Health
Serum
Population
Neoplasms

Keywords

  • Biomonitoring
  • Chromosome rearrangements
  • Cytogenetic damage
  • Depleted uranium
  • DNA adducts
  • Micronuclei
  • Oxidative damage
  • Xenobiotics

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Biological monitoring of Italian soldiers deployed in Iraq. Results of the SIGNUM project. / Bolognesi, Claudia; Migliore, Lucia; Lista, Florigio; Caroli, Sergio; Patriarca, Marina; De Angelis, Roberta; Capocaccia, Riccardo; Amadori, Sergio; Pulliero, Alessandra; Balia, Cristina; Colognato, Renato; La Gioia, Vincenzo; Bonassi, Stefano; Izzotti, Alberto.

In: International Journal of Hygiene and Environmental Health, Vol. 219, No. 1, 01.01.2016, p. 24-32.

Research output: Contribution to journalArticle

Bolognesi, C, Migliore, L, Lista, F, Caroli, S, Patriarca, M, De Angelis, R, Capocaccia, R, Amadori, S, Pulliero, A, Balia, C, Colognato, R, La Gioia, V, Bonassi, S & Izzotti, A 2016, 'Biological monitoring of Italian soldiers deployed in Iraq. Results of the SIGNUM project', International Journal of Hygiene and Environmental Health, vol. 219, no. 1, pp. 24-32. https://doi.org/10.1016/j.ijheh.2015.08.001
Bolognesi, Claudia ; Migliore, Lucia ; Lista, Florigio ; Caroli, Sergio ; Patriarca, Marina ; De Angelis, Roberta ; Capocaccia, Riccardo ; Amadori, Sergio ; Pulliero, Alessandra ; Balia, Cristina ; Colognato, Renato ; La Gioia, Vincenzo ; Bonassi, Stefano ; Izzotti, Alberto. / Biological monitoring of Italian soldiers deployed in Iraq. Results of the SIGNUM project. In: International Journal of Hygiene and Environmental Health. 2016 ; Vol. 219, No. 1. pp. 24-32.
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abstract = "Background: Leukemia/lymphoma cases reported in 2001 among United Nation soldiers or peacekeepers deployed to the Balkans aroused alert on the exposure to depleted uranium. Recent epidemiological studies carried out in different European countries among peacekeepers who served in the Balkans failed to demonstrate a higher than expected risk of all cancers but, mostly due to their limitations in size and follow up time, leave open the debate on health risk of depleted uranium. The aim of SIGNUM (Study of the Genotoxic Impact in Military Units) was to identify potential genotoxic risk associated with the exposure to depleted uranium or other pollutants in the Italian Army military personnel deployed in Iraq. Methods: Blood and urine samples were collected before and after the deployment from 981 Italian soldiers operating in Iraq in 2004-2005. As, Cd, Mo, Ni, Pb, U, V, W, and Zr were determined in urine and serum. DNA-adducts, 8-hydroxy-2'-deoxyguanine and micronuclei frequency were evaluated in blood lymphocytes. Three different genetic polymorphisms, GSTM1, XRCC1, OGG1 were analyzed. Results: Significant T0-. T1 reduction in the total concentration of uranium, increases for Cd, Mo, Ni, Zr, and decreases for As, Pb, W, and V in urine and plasma were observed. Increases in oxidative alterations and in micronuclei frequency, included in the range of values of non-occupationally exposed populations, were observed at the end of the period of employment. Conclusions: Our results did not detect any toxicologically relevant variation of DNA-damage biomarkers related to the deployment in the operational theater.",
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AU - Patriarca, Marina

AU - De Angelis, Roberta

AU - Capocaccia, Riccardo

AU - Amadori, Sergio

AU - Pulliero, Alessandra

AU - Balia, Cristina

AU - Colognato, Renato

AU - La Gioia, Vincenzo

AU - Bonassi, Stefano

AU - Izzotti, Alberto

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N2 - Background: Leukemia/lymphoma cases reported in 2001 among United Nation soldiers or peacekeepers deployed to the Balkans aroused alert on the exposure to depleted uranium. Recent epidemiological studies carried out in different European countries among peacekeepers who served in the Balkans failed to demonstrate a higher than expected risk of all cancers but, mostly due to their limitations in size and follow up time, leave open the debate on health risk of depleted uranium. The aim of SIGNUM (Study of the Genotoxic Impact in Military Units) was to identify potential genotoxic risk associated with the exposure to depleted uranium or other pollutants in the Italian Army military personnel deployed in Iraq. Methods: Blood and urine samples were collected before and after the deployment from 981 Italian soldiers operating in Iraq in 2004-2005. As, Cd, Mo, Ni, Pb, U, V, W, and Zr were determined in urine and serum. DNA-adducts, 8-hydroxy-2'-deoxyguanine and micronuclei frequency were evaluated in blood lymphocytes. Three different genetic polymorphisms, GSTM1, XRCC1, OGG1 were analyzed. Results: Significant T0-. T1 reduction in the total concentration of uranium, increases for Cd, Mo, Ni, Zr, and decreases for As, Pb, W, and V in urine and plasma were observed. Increases in oxidative alterations and in micronuclei frequency, included in the range of values of non-occupationally exposed populations, were observed at the end of the period of employment. Conclusions: Our results did not detect any toxicologically relevant variation of DNA-damage biomarkers related to the deployment in the operational theater.

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