Biological optimization of simultaneous boost on intra-prostatic lesions (DILs): Sensitivity to TCP parameters

R. Azzeroni, A. Maggio, C. Fiorino, P. Mangili, C. Cozzarini, F. De Cobelli, N. G. Di Muzio, R. Calandrino

Research output: Contribution to journalArticlepeer-review


The aim of this investigation was to explore the potential of biological optimization in the case of simultaneous integrated boost on intra-prostatic dominant lesions (DIL) and evaluating the impact of TCP parameters uncertainty.Different combination of TCP parameters (TD50 and γ50 in the Poisson-like model), were considered for DILs and the prostate outside DILs (CTV) for 7 intermediate/high-risk prostate patients. The aim was to maximize TCP while constraining NTCPs below 5% for all organs at risk. TCP values were highly depending on the parameters used and ranged between 38.4% and 99.9%; the optimized median physical doses were in the range 94-116Gy and 69-77Gy for DIL and CTV respectively. TCP values were correlated with the overlap PTV-rectum and the minimum distance between rectum and DIL. In conclusion, biological optimization for selective dose escalation is feasible and suggests prescribed dose around 90-120Gy to the DILs. The obtained result is critically depending on the assumptions concerning the higher radioresistence in the DILs. In case of very resistant clonogens into the DIL, it may be difficult to maximize TCP to acceptable levels without violating NTCP constraints.

Original languageEnglish
Pages (from-to)592-598
Number of pages7
JournalPhysica Medica
Issue number6
Publication statusPublished - Nov 2013


  • Biological optimization
  • NTCP
  • Prostate radiotherapy
  • TCP

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Physics and Astronomy(all)


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