Biological parameters influencing the immunological response to plasma derived and recombinant hepatitis B vaccines

Maria Cristina Honorati, Erminia Mariani, Paolo Dolzani, Andrea Facchini, R. Ansaloni, L. Bonazzi, A. Giamperoli, G. Guerra, M. Martuzzi, M. Monti, M. C. Pirazzini, M. Tangenti, M. Baraldini, C. A. Busachi, M. Capelli, R. Da Re, G. Finzi, F. Giorgetti, M. Magnani, R. MinieroE. Pisi, G. Sprovien, U. Volta, M. Zanetti, G. Giuliani Piccari, A. Accogli, A. M. Borrelli, P. Cacciari, A. Pizzoferrato, A. Ragazzi, G. Risi

Research output: Contribution to journalArticlepeer-review


Personnel (1856 subjects) belonging to local health units (medical and paramedical staff) that have been vaccinated since 1984 against hepatitis B virus (HBV) with HBsAg plasma purified preparations (Hevac-B and H-B-Vax) or recombinant DNA preparation (Engerix-B) were followed in plasma anti-HBs antibody levels. At the end of the protocols, different seroconversion percentages and different anti-HBs levels were reached: the best results were obtained with Engerix-B. Sex and principally age influenced the antibody production: women generally reached highest protective antibody levels and the 21-30 year group was more responsive than other groups. The injection of a supplementary 4th or 5th dose in low or non-responders could restore the specific immunity in the majority of the subjects and increase the anti-HBs level. The time course after the immunization of antibody levels depended on the level reached at the end of vaccination schedule. These data suggest that different antibody level monitorings of vaccinated subjects, planned on the basis of the antibody level reached at the end of vaccination, could prvent a loss of protection against the HBV infection.

Original languageEnglish
Pages (from-to)369-374
Number of pages6
JournalAnnali dell'Istituto Superiore di Sanita
Issue number3
Publication statusPublished - 1996


  • antibodies
  • hepatitis B
  • vaccine schedule

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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