Biological predictors of response to radiotherapy in cervical carcinomas

Maria Grazia Daidone, Umberto Ricardi, Silvia Veneroni, Alessandra Faranda, Elvira Benini, Alessandro Urgesi, Gian Luca Sannazzari, Rosella Silvestrini

Research output: Contribution to journalArticle

Abstract

On 21 patients with T1b-T3b tumours subjected to external radiotherapy and brachytherapy, the expression of P53 and glutathione S-transferase π [GST-π], immunohistochemically detected, the S-phase cells fraction (3H-thymidine labeling index, TLI) and DNA content evaluated by image analysis were determined on biopsies before and after the first 10 Gy. P53 accumulation was reduced in 60% of P53-overexpressing tumours and not induced in P53-negative tumours, GST-π was induced in about 40% of pretreatment GST-π-negative cases, TLI was reduced in 70% of the cases regardless of pretreatment values, and DNA profiles remained unchanged in two-thirds of the cases. P53 accumulation was a predictor of 3-year relapse-free survival after radiotherapy, followed by GST-π expression, whereas TLI did not influence prognosis.

Original languageEnglish
Pages (from-to)41-46
Number of pages6
JournalInternational Journal of Oncology
Volume10
Issue number1
Publication statusPublished - Jan 1997

Keywords

  • Cell proliferation
  • Cervical carcinoma
  • DNA ploidy
  • GST-π expression
  • P53 expression
  • Radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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  • Cite this

    Daidone, M. G., Ricardi, U., Veneroni, S., Faranda, A., Benini, E., Urgesi, A., Sannazzari, G. L., & Silvestrini, R. (1997). Biological predictors of response to radiotherapy in cervical carcinomas. International Journal of Oncology, 10(1), 41-46.