Abstract
Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, Syt-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.
| Original language | English |
|---|---|
| Pages (from-to) | 4519-4526 |
| Number of pages | 8 |
| Journal | Anticancer Research |
| Volume | 25 |
| Issue number | 6 C |
| Publication status | Published - Nov 2005 |
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Keywords
- Prognostic factors
- Review
- Soft tissue sarcomas
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Biological prognostic factors in adult soft tissue sarcomas. / Ottaiano, Alessandro; De Chiara, Anna; Fazioli, Flavio; Talamanca, Annarita Aiello; Mori, Stefano; Botti, Gerardo; Milano, Amalia; Apice, Gaetano.
In: Anticancer Research, Vol. 25, No. 6 C, 11.2005, p. 4519-4526.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Biological prognostic factors in adult soft tissue sarcomas
AU - Ottaiano, Alessandro
AU - De Chiara, Anna
AU - Fazioli, Flavio
AU - Talamanca, Annarita Aiello
AU - Mori, Stefano
AU - Botti, Gerardo
AU - Milano, Amalia
AU - Apice, Gaetano
PY - 2005/11
Y1 - 2005/11
N2 - Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, Syt-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.
AB - Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, Syt-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.
KW - Prognostic factors
KW - Review
KW - Soft tissue sarcomas
UR - http://www.scopus.com/inward/record.url?scp=28444442575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28444442575&partnerID=8YFLogxK
M3 - Article
C2 - 16334136
AN - SCOPUS:28444442575
VL - 25
SP - 4519
EP - 4526
JO - Anticancer Research
JF - Anticancer Research
SN - 0250-7005
IS - 6 C
ER -