Biological prognostic factors in adult soft tissue sarcomas

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, Syt-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.

Original languageEnglish
Pages (from-to)4519-4526
Number of pages8
JournalAnticancer Research
Volume25
Issue number6 C
Publication statusPublished - Nov 2005

Fingerprint

Biological Factors
Sarcoma
Neoplasm Metastasis
Neoplasms
Cyclins
beta Catenin
Cadherins
Genetic Markers
Vascular Endothelial Growth Factor A
Lymph Nodes
Bone and Bones
Recurrence
Lung
Liver
Surveys and Questionnaires
Therapeutics

Keywords

  • Prognostic factors
  • Review
  • Soft tissue sarcomas

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Biological prognostic factors in adult soft tissue sarcomas. / Ottaiano, Alessandro; De Chiara, Anna; Fazioli, Flavio; Talamanca, Annarita Aiello; Mori, Stefano; Botti, Gerardo; Milano, Amalia; Apice, Gaetano.

In: Anticancer Research, Vol. 25, No. 6 C, 11.2005, p. 4519-4526.

Research output: Contribution to journalArticle

@article{ae1d1b0361114baaab9f7a23961d277a,
title = "Biological prognostic factors in adult soft tissue sarcomas",
abstract = "Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, Syt-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.",
keywords = "Prognostic factors, Review, Soft tissue sarcomas",
author = "Alessandro Ottaiano and {De Chiara}, Anna and Flavio Fazioli and Talamanca, {Annarita Aiello} and Stefano Mori and Gerardo Botti and Amalia Milano and Gaetano Apice",
year = "2005",
month = "11",
language = "English",
volume = "25",
pages = "4519--4526",
journal = "Anticancer Research",
issn = "0250-7005",
publisher = "International Institute of Anticancer Research",
number = "6 C",

}

TY - JOUR

T1 - Biological prognostic factors in adult soft tissue sarcomas

AU - Ottaiano, Alessandro

AU - De Chiara, Anna

AU - Fazioli, Flavio

AU - Talamanca, Annarita Aiello

AU - Mori, Stefano

AU - Botti, Gerardo

AU - Milano, Amalia

AU - Apice, Gaetano

PY - 2005/11

Y1 - 2005/11

N2 - Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, Syt-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.

AB - Adult soft tissue sarcomas (STSs) are a rare group of highly heterogeneous neoplasms arising in different tissues. They are locally aggressive and can produce recurrence and distant metastasis. The most common metastatic sites are lung, lymph nodes, liver, bone and soft tissues. Staging for STSs has been based on some prognostic information: grade (low vs. intermediate/high grade), size (small vs. large tumors), depth of infiltration (superficial vs. deep neoplasms) and presence or not of distant metastasis. In the last 10 years, a plethora of new markers (proliferation markers and DNA alteration, P-gp, p53, TLS-CHOP, cyclins, survivin, TERT, PAX3-PAX7/FKHR, Syt-SSX1/2, VEGF, E-cadherin and beta-catenin, nm23, SKP-2, p27, CD40) has been studied with regard to their role in promoting progression (in a laboratory setting) and then determining prognosis and therapy (in a clinical setting). In the present survey, we focused on the role of new biological prognostic factors in STSs and also reported the quality of such studies with an ad hoc designed questionnaire.

KW - Prognostic factors

KW - Review

KW - Soft tissue sarcomas

UR - http://www.scopus.com/inward/record.url?scp=28444442575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=28444442575&partnerID=8YFLogxK

M3 - Article

C2 - 16334136

AN - SCOPUS:28444442575

VL - 25

SP - 4519

EP - 4526

JO - Anticancer Research

JF - Anticancer Research

SN - 0250-7005

IS - 6 C

ER -